Çocukluk çağı hemanjiomlarının klinik özellikleri ve tedavi yöntemleri

Hemanjiomlar çocukluk çağında en sık görülen konjenital anomalidir. Hemanjiomlar genellikle sorun yaratmaz. Küçük bir bölüm hemanjiom ise doku harabiyetine yol açması, boyutu, yeri ya da agresif büyümesi nedeniyle süt çocuğunda sorun yaratabilir. Hemanjiomların patogenezi çok iyi anlaşılamamıştır, fakat son bulgular vasküler homeostazisteki regülasyon bozukluğu ile vasküler fenotipin ortaya çıktığını desteklemektedir. Bu derlemede bu tümörlerin patogenezi ile ilgili yeni bilgiler, probleme neden olan sendromik hemanjiomları da içeren kaygı verici prezantasyonları sunulmuştur. Ayrıca tedavi stratejileri ve tedavi seçenekleri tartışılmıştır.

Clinical characteristics and treatment modalities of childhood hemangiomas

Hemangiomas are the most common type of congenital anomaly in childhood. Fortunately, most hemangiomas only grow to small size and do not cause problems. However, there is a small subset of hemangiomas that destroy tissue or endanger the infant's life, either because of tumor's size, location or agressive growth. The pathogenesis of hemangiomas is not well understood, but recent findings suggest a unique vascular phenotype with dysregulated vascular homeostasis. This article reviews new information regarding the pathogenesis of these tumors and highlights the more worrisome presentations, including syndromic hemangiomas, that are likely to be problematic. In addition, management strategies and treatment options are discussed.

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