Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study
Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study
In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
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- Radwan, R.R., and Abdel Fattah, S.M., “Mechanisms involved in the possible nephroprotective effect
of rutin and low dose γ irradiation against cisplatin-induced nephropathy in rats”, Journal of
Photochemistry and Photobiology B Biology, 169: 56–62, (2017).
- Shaik, A.N., Altomare, D.A., Lesko, L.J., and Trame, M.N., “Development and validation of a LC–
MS/MS assay for quantification of cisplatin in rat plasma and urine”, Journal of Chromatography B,1046:
243–249, (2017).
- Nasr, A.Y., “Protective effect of aged garlic extract against the oxidative stress induced by cisplatin
on blood cells parameters and hepatic antioxidant enzymes in rats”, Toxicology Reports, 1: 682–691,
(2014).
- Yang, Z., Schumake, L.M., Egorin, M.J., E.G., Zuhowski, Z., and Guo, K.J., “Cisplatin preferentially
binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane
of head and neck squamous cell carcinoma: possible role in apoptosis”, Clinical Cancer Research, 12:
5817–5825, (2006).
- Omar, H.A., Mohameda, W.R., Arafa, E.A., Shehata, B.A., El Sherbincy, G.A., Arab, H.H., and
Elgendy, A.N., “Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its
antitumor activity”, Pharmacological Reports, 68: 349–356, (2016).
- Callejo, A., Durochat, A., Bressieux, S., Saleur, A., Chabbert, C., Juan, I.D., Llorens, J., and
Gaboyard-Niay, S., “Dose-dependent cochlear and vestibular toxicity of trans-tympanic cisplatin in the
rat”, NeuroToxicology, 60: 1–9, (2017).
- Heeba, G.H., Hamza, A.A., and Hassanin, S.O., “Induction of heme oxygenase-1 with hemin
alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate
cancer cell line”, Toxicological Letters, 264: 38–50, (2016).
- Reddy, K.P., Madhu, P., and Reddy, P.S., “Protective effects of resveratrol against cisplatin-induced
testicular and epididymal toxicity in rats”, Food and Chemical Toxicology, 91: 65-72, (2016).
- El-Awady, E.E., Moustafa, Y.M., Abo-Elmatty, D.M., and Radwan, A., “Cisplatin-induced
cardiotoxicity: Mechanisms and cardioprotective strategies”, European Journal of Pharmacology, 650:
335–341, (2011).
- Hassan, M.S., Morgan, A.M., Mekawy, M.M., Zaki, A.R., and Ghazi, Z.M., “Teratogenic effect of
cisplatin in rats and the protective role of sodium selenite”, Experimental Toxicology and Pathology, 68:
277–287, (2016).
- Szentmihályi, K., Maya, Z., Szénási, G., Máthé, C., Sebestény, A., Albert, M., Hegyi, G., and
Blázovics, A., “Changes of essential element content and prevention of cisplatin induced oxidative stress
in rat liver by CV247 administration”, European Journal of Integrative Medicine, 8: 36–41, (2016).
- Kılıc, C., Gülec-Peker, E.G., Acartürk, F., Sarı Kılıcaslan, S.M., and Coskun-Cevher, S.,
“Investigation of the effects of local glutathione and chitosan administration on incisional oral mucosal
wound healing in rabbits”, Colloid Surface, B 112: 499–507, (2013).
- Kaltalioglu, K.,and Coskun-Cevher, S., “Potential of morin and hesperidin in the prevention of
cisplatin-induced nephrotoxicity”, Renal Failure, 38: 1291–1299, (2016).
- Apaydın, F.G., Bas, H., Kalender, S., and Kalender, Y., “Bendiocarb induced histopathological and
biochemical alterations in rat liver and preventive role of vitamins C and E”. Environmental Toxicology
and Pharmacology, 49: 148–155, (2017).
- Uzun, F.G., and Kalender, Y., “Chlorpyrifos induced hepatotoxic and hematologic changes in rats:
The role of quercetin and catechin”, Food and Chemical Toxicology, 55: 549-556, (2013).
- Shehata, A.S., Amera, M.G., Abd El-Haleem, M.R., and Karam RA., “The ability of hesperidin
compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino
rats: A histological and biochemical study”, Experimental Toxicology and Pathology, 69: 203–212,
(2017).
- Zareei, S., Boojar, M.M.A., and Amanlou, M., “Inhibition of liver alanine aminotransferase and
aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study”, Life
Sciences, 178: 49–55, (2017).
- Sultana, F., Neog, M.K., and Rasool, M.K., “Targeted delivery of morin, a dietary bioflavanol
encapsulated mannosylated liposomes to the macrophages of adjuvant-induced arthritis rats inhibits
inflammatory immune response and osteoclastogenesis”, European Journal of Pharmaceutics and
Biopharmaceutics, 115: 229–242, (2017).
- Khan, M.H.A., and Parvez, S., “Hesperidin ameliorates heavy metal induced toxicity mediated by
oxidative stress in brain of Wistar rats”, Journal of Trace Elements in Medicine and Biology, 31: 53–60,
(2015).
- Mahmoud, A..M, Ashour, M.B., Abdel-Moneim, A., and Ahmed, O.M., “Hesperidin and naringin
attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat
fed/streptozotocin-induced type 2 diabetic rats”, Journal of Diabetes and its Complications, 26: 483–90,
(2012).
- Jung, K., An, J.M., Eom, D., Kang, K.S., and Kim, S., “Preventive effect of fermented black ginseng
against cisplatin-induced nephrotoxicity in rats”, Journal of Ginseng Research, 41: 188-194, (2017).
- Tilyek, A., Chai, C., Hou, X., Zhou, B., Zhang, C., Cao, Z., and Yu, B., “The protective effects of
Ribes diacanthum Pallon cisplatin-induced nephrotoxicity in mice”, Journal of Ethnopharmacology, 178:
297–306, (2016).
- Ongjanović, B.I., Marković, S.D., ĐorŠđević, N.Z., Trbojević, I.S., Štajn, A.Š., and Saičić, Z.S.,
“Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes:
Protective role of coenzyme Q10 and Vitamin E”, Reproductive Toxicology, 29: 191-197, (2010).
- Elhalwagy, M.E.A., Darwish, N.S., and Zaher, E.M., “Prophylactic effect of green tea polyphenols
against liver and kidney injury induced by fenitrothion insecticide”, Pesticide Biochemistry and
Physiology, 91: 81-89, (2008).
- Manucha, W., and Vallés, P.G., “Apoptosis modulated by oxidative stress and inflammation during
obstructive nephropathy”, Inflammation and Allergy - Drug Targets, 11: 303-12, (2012).
- Ozbek, E., “Induction of oxidative stress in kidney”, International Journal of Nephrology, 2012: 465-
897, (2012).
- Apaydın, F.G, Bas, H., Kalender, S., Kalender, Y., “Subacute effects of low dose lead nitrate and
mercury chloride exposure on kidney of rats”, Environmental Toxicology and Pharmacology, 2016:
41:219-224.
- Harborne, J.B., and Williams, C.A., “Advantages in flavonoid research since 1992”, Phytochemistry,
55: 481-504, (2000).
- Ke, Y., Liu, C., Hao, J., Lu, L., Lu, N., Wu, Z., Zhu, S., and Chen, X., “Morin inhibits cell
proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose
condition”, Biomedicine and Pharmacotherapy, 84: 622–627, (2016).