Stereolitografi ile üç boyutlu (3B) biyobaskılanmış yapay kalp kapakçıklarının biyouyumluluk özelliklerinin analizi

Her geçen yıl organ transplantasyonu için organ nakli ihtiyacı sürekli olarak geometrik ölçeklerde artmıştır.Organ nakline ihtiyaç sürekli olarak artarken organ bağısı sayısında ise ciddi bir artış gözlenmemiştir. Organnakline en çok ihtiyaç duyulan alanlardan bir tanesi ise kalp kapakçığı hastalıklarıdır. Biyoprostetik vemekanik kalp kapakçıklarının kendi içerisinde pek çok sorun bulundurmakta bu nedenle yeterli tedaviyisağlayamamaktadır. Bütün bu sebepler dolayısıyla doku mühendisliği aracılığı ile kişinin kendi kök hücrelerikullanarak oluşturulabilen, biyouyumluluğu yüksek yapay kalp kapakçıkları üretmek mecburidir. Buçalışmada amaçlanan, kalp kapakçıkları hastalıklarında kullanılmak üzere stereolitografi yöntemi ileüretilmiş yapay bir kalp kapakçığı üretmektir. Stereolitografi yöntemi yüksek çözünürlüğe sahip son derecegüçlü mekanik özelliklere sahip olan yapılar üretme konusunda bütün diğer 3B baskı modellerinden öndeolsa da biyoyazıcı olarak değerlendirilmemiştir. Bu çalışma da bu başarılmaya çalışılmış ve üretilmiş olankalp kapakçıklarının biyouyumluluk özellikleri detaylı olarak analiz edilmiştir.

Analysis of biocompatibility characteristics of stereolithography applied three dimensional (3D) bioprinted artifical heart valves

Each and every year, there has been an ever-increasing demand for organ transplants in geometric scales. There are no significant increase observed in organ donations while the need for organ transplantation is keep increasing. Organ donation emerges as the most feasible solution especially in heart valve diseases. Bioprostetic and mechanical valves have serious intrinsic problems and therfore they do not provide sufficent treatment for heart valve deficiencies. Due to these reasons, growing or fabricating tissue engineered heart valves using biomaterial scaffolds with a person’s own stem cells with high biocompatability is an obligatory. The purpose of this study is; fabricating 3D artificial heart valves by stereolithography that has potential to be obtained for heart valve replacements. Stereolithography has proven potential for fabricating 3D models with high structural integrity and strong mechanical properties, yet it has not been evaluated as a bioprinter. In this study, this purpose is aimed to be succeeded and analyzed detailed biocompatibility characteristics of fabricated heart valves.

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