Hüseyin TÜRKER, Turan GÜVEN, Mustafa YEL

Ultravioleye maruz bırakılan kör farenin (Spalax leucodon) tiroit bezi foliküler hücrelerindeki ince yapı değişmeleri

Ultraviyole (UV) radyasyonu ile ışınlanan kör farelerin (Spalax leucodon) tiroit bezi foliküler hücrelerinde meydana .gelen ince yapı değişmeleri transmisyon elektron mikroskobu (TEM) ile incelenmiştir. Vücut ağırlığı 150-200 g arasındaki kör fareler, her gün 8 saat olmak üzere 52, 112, 168 ve 224 saat süre ile UV radyasyonuna maruz bırakılmıştır. Uygulamanın ardından hayvanlardan tiroit bezi örnekleri alınmış ve TEM için preparasyonları yapılmıştır. Uygulanan doz miktarı ve süreye bağlı olarak deney safhalarındaki hayvanlardan alınan tiroit bezi foliküler hücrelerinde vakuolleşme, lizozomlarda artış, endoplâzmik retikulumlarda genişleme ve ve/ikülleşme, lümene bakan mikrovilluslarda kaybolma görülmüştür.

Ultrastructural changes in thyroid follicular cells of molerat (Spalax leucodon) exposed to ultraviolet light

The effects of ultraviolet (UV) irradiation on the follicular cells of thyroid glands of molerats (Spalax leucodon) have been investigated by transmission electron microscope (TEM). Molerats, approximately body weight of 150-200 g were used in experiments. The animals were exposed to UV radiation of 52, 112, 168-and 224 hours (eight hours in a day). Samples of thyroid glands were obtained from each animal and made of preparation for TEM. Vacuolation in the cytoplasm, increases in the number of lysosomes, dilatation and vesiculation of endoplasmic reticulum, loss of microvilli have been in the follicle cells ofbthyroid glands obtained from molerats depending on doses and experimantal periods.

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