Effects of ultraviolet radiation on total plasma T3, total plasma T4 and TSH hormones in molerat (Spalax leucodon)

Bu çalışmada, UV-C radyasyonunun plâzma toplam To, plazma toplam T4 ve TSH hormonları üzerine etkileri çalışılmıştır. Denemelerde vücut ağırlığı 150-200 g arasında değişen erkekli dişili 11 adet kör fare (Spalax leucodon) kullanılmıştır. Radyasyon uygulamasına başlamadan bir gün önce hayvanlardan kontrol için kan örnekleri alınmıştır. Bir gün sonrasından başlanmak üzere her gün 8 saat süre ile kör farelere 60 gün boyunca UV radyasyonu uygulanmıştır. Uygulamanın 7, 14, 21, 28, 45 ve 60. günleri sonunda deneme gruplarından kan örnekleri alınarak, plâzma toplam T-,, plazma toplam T- ve TSH düzeyleri ölçülmüştür. Buna göre, çalışmanın 60. gününe kadar toplam Tg ve toplam T, düzeylerinde anlamlı bir düşüş (p

Ultraviyole radyasyonunun kör farelerin (Spalax leucodon) plazma toplam T3, plazma toplam T4 ve tesh hormonları üzerine etkisi

The effects of ultraviolet (UV-C) irradiation on the plasma total Tg, plasma total T^ and TSH hormones of molerats (Spalax leucodon) have been examined. 11 molerats, approximately body weight of 150-200 g were used in experiments. Before the experiments, bloods samples were taken from the animals as control. The animals were exposed to UV-C radiation for 60 days (eight hours a day). At the end of 7th, 14th, 21th, 28th, 45th and 60th days of study, the blood samples were taken from the experimental groups and then total plasma levels of T_, T* and TSH were determined. According to results obtained from the experiments, the total T, and T^ levels in plasma showed a significant decrease (p

___

  • 1. WHO, Ultraviolet radiation environmental health criteria, 14, Geneva (1979).
  • 2. WHO, Environmental health criteria 160: Ultraviolet radiation, Geneva (1994).
  • 3. Giese, A.C., Living with our sun's ultraviolet rays, Plenum Press, New York and London, 1-256 (1969a).
  • 4. Stolarski, E., "The Antarctic ozone hole", ScLAmer., 258: 1,20-27(1988).
  • 5. Yel, M. ve Güven, T., "Ultraviyole ışığının Spalax leucodon epidermisi üzerindeki etkileri", X.Ulusal Biyoloji Kongresi, Genel Biyoloji Bildirileri, Erzurum (1990).
  • 6. Schwartz, E., "Connective tissue alterations in the skin of ultraviolet irradiated hairless mice", J. Invest.Dermatol, 9.1: 158-161 (1988).
  • 7. Gange, R.W. and Rosen, C.F., "UV-A effects on mammalian skin and cells", Vhotochem. Photobiol., 43, 6:701-705(1986).
  • 8. Bisset, D.L., Hannon, D.P. and Orr, T.V., "An animal model of solar-aged skin: Histological, physical and visible changes in UV-irradiated hairless mouse skin", Photochem. Photobiol., 46, 3: 367-378 (1987).
  • 9. Philips, R.M., "X-ray-induced changes in function and structure of the rat parotid gland", /. Oral Surgery.,28:432-437(1970).
  • 10.Sikov, M.R., Mahlum, D.D. and Howard, E.B., "Effect of age on the morphologic response of the rat thyroid to irradiation by iodine-131", RadiaLRes., (49): 233-244 (1972).
  • 11.Messelt, E.B. and Dahi, E., "Influence of X-ray irradiation on the ultrastructure of rat submandibular gland striated-duct cells", Ada. Odontol Scand., 41(5): 277-282 (1983).
  • 12.Ahlersova, E., Molcanova, A., Ahlers, I., "Thyroid hormones in gamma irradiated rats", Radiobiol Radiothen., (29): 507-512 (1988).
  • 13.Lerma, E., Hevia, A., Rodrigo, P., Gonzalez, C.R., Armas, J.R. and Galera, H., "The effect of He-Ne laser radiation on the thyroid gland of the rat", Int. J. Exp. Path., (72): 379-385 (1991).
  • 14.Giese, A.C., "Effects of ultraviolet radiation on some activities of animal cells, In the biologic effects of ultraviolet radiation", edited by F. Urbach, Pergamon Press,Oxford: 61-82 (1969b).
  • 15.Johnston, K.J., Oikarinen, A.I., Lowe, N.J., Clark, J.G., and Uitto, J., "Ultraviolet radiation-induced connective tissue changes in the skin of hairles mice", /. Invest. Dermatol., (82): 587-590 (1984).
  • 16.Yamauchi, K., Luo, R.P. and Ogura, R., "Effect of ultraviolet light exposure on lipid peroxide formation of isolated mitochondria from rat liver administered 8-methoxypsoralen", Kurume Med. J., 25(3): 169-173(1978).
  • 17.Türker, H., Güven, T. ve Yel, M., "Ultraviyoleye maruz bırakılan kör farenin (Spalax leucodon) tiroit bezi foliküler hücrelerindeki ince yapı değişmeleri", Gazi Ün. Fen. Bilim. Enst. Dergisi, Vol. 13, No:4: 855-870(2000).
  • 18.Candan, S. ve Güven, T., "Normal ve ultraviyole ile ışınlanmış Spalax leucodon (Rodentia:Splacidae)'da kan sayımı ve kan hücrelerinin ışık mikroskobu ile incelenmesi", Gazi Ün. Fen Bilim. Enst. Dergisi., 9(1):41-53 (1996).
  • 19.Riesco, G. Taurog, A., Larsen, P.R. and Krulich, L., "Acute and chronic responses to iodine deficiency inrats", Endocrinology, 100: 303 (1977).
  • 20.Mateyko, G.M. and Edelman, A., "The effects of localized cathode ray particle irradiation of the hypophysis and whole body x-irradiation on gonadotropin, thyrotropin and adrenocorticotropin of the rat pituitary",Radiat. Res., (1): 470-482 (1954).
  • 21.Litten, R.Z., Carr, F.E., Fein, H.G. and Smallridge, R.C., "Effects of irradiation and semistarvation on rat thyrotropin beta subunit messenger ribonucleic acid, pituitary thyrotropin content, and thyroid hormone levels", Life-Scl, 47(16): 1409-17 (1990).
  • 22.Song, C.W. and Evans, T.C., "The effect of whole body irradiation on thyroid function in the mouse",Radiat. Res., (33): 480-489 (1968).
  • 23.Ahlersova, E., Kassayova, M. and Ahlers, I., "Serum melatonin, corticosterone and thyroid hormones in irradiated rats: Effect of exposure during various times of day and of light regimen", J. Physiol. Pharmacol.,48(3): 435-42 (1997).
  • 24.Gray,V.M., Ratclliffe, W.A. Orr, J.S., "The effect of whole-body irradiation on the serum levels and kinetics of thyroid hormones in rats", /. Radiat. Biol, (37): 653-666 (1980).
  • 25.Sterling, K., Brenner, M.A., Newman, E.S., Odel, W.D. and Bellabarba, D., "The significance of euthyroid status after treatment of hyperthyroidism", J. Clin. Endocrinol Metab., (33): 729 (1971).
  • 26.van Doom, J., Roelfsema, F. and van der Heide, D., "The effect of propylthiouracil and methimazole on the peripheral conversion of thyroxine to 3, 5, 3'-triiodothyronine in athyreotic thyroxine-maintained rats", Acta Endocrinol. (Kbh), (103): 509 (1983).