Lütfü HANOĞLU, Şeyma KILIÇ, Fahriye Feriha ÖZER, Nesrin Helvacı YILMAZ

Lower Extremity Tremor Exacerbation due to Rivastigmine Administration for Treatment of Parkinson’s Disease Dementia

Rivastigmin Parkinson Hastalığı Demansı'nın (PHD) tedavisinde kullanılan etkili bir tedavilerden birisidir. Rivastigmin tedavisi uygulanan hastalarda sıklıkla üst ekstremitelerde istirahat tremor görülür ve genellikle hafiftir, tedavinin kesilmesine neden olmaz. Rivastigmin bant PHD tanısı almış iki hastamıza verdik ve doz artımı sonrası aylar içinde her ikisinde de ayağa kalkınca ortaya çıkan postural instabilite ve alt ekstremite tremoru gelişmiştir. İlacın dozunun azaltılması alt ekstremite tremoru belirgin şekilde kaybolmuştur. Rivastigmin doz arttırılmasına bağlı özürleyici alt ekstremite tremoru daha önce bildirilmemiştir. Bu olgu sunumunda nadir görülen bu yan etkiye dikkat çekmek ve ilacı kesmemek gerektiğini vurgulamak istedik

Parkinson Hastalığı Demansı’nın Tedavisi için Uygulanan Rivastigmine Bağlı Gelişen Alt Ekstremite Tremor Ekzaserbasyonu

Rivastigmine is one of the approved effective treatments for Parkinson's Disease Dementia (PDD). Increase of upper extremity resting tremor is a common adverse effect seen in patients administered rivastigmine and is usually mild, not leading to treatment withdrawal. Rivastigmine patch was given to both of our patients diagnosed with PDD and they suffered from postural instability and lower extremity tremor that occurred while standing and disappeared with walking after the administration and increase dosage of the drug in a few months time. The lower extremity tremor disappeared markedly in both patients after the dose reduction. Disabling lower extremity tremor due to rivastigmine dosage increase has not been reported before. We want to draw attention to this rare side effect through these patients and mention not to quit the drug

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