Selma TOKUÇOĞLU, Sefa KELEKÇİ, İsmet İNAN, Handan KELEKÇİ

Impaired glucose tolerance in pregnant women with vaginal candidiasis

Amaç: Çalışmanın amacı vaginal candidiasis' in gebe kadınlarda bozulmuş glukoz toleransını belirlemede bir risk faktörü olup olmadığını belirlemek. Materyal ve Metod: Mikroskopisi pozitif 64 vaginal candidiasis' U gebe kadın ile 59 Candida negatif kontrol vakasına gebeliklerinin 24 ile 28. haftasında 75 gm oral glukoz tolerans testi uygulandı. Vakaların demografik özellikleri, glukoz seviyeleri ve gestasyonel diyabet oranları istatistiksel olarak karşılaştırıldı. Bulgular: Demografik özellikler açısından her iki grup arasında fark yoktu. 75 gm glukoz alımından sonra açlık(88 vs 84mg /dL, p=0.02), 30. dakika (138 vs 126 mg/dL, p=0.05) ve 60. dakika kan şekerleri(124 vs 106 mg/dL, p=0.01) vaginal candidiasis'li gebe kadınlarda belirgin yüksekti. İki grup arasında 120. dakika kan şekerleri ve gestasyonel diyabet oranlan açısından belirgin fark saptanmadı. Sonuçlar: Vaginal candidiasis'li gebe kadınlarda glukoz toleransı bozulduğu saptandı. Bu yorumu desteklemek için iyi planlanmış daha geniş prospektif vaka kontrol çalışmalarına ihtiyaç vardır.

Vaginal kandidiasis'li gebe kadınlarda bozulmuş glukoz toleransı

Purpose: To evaluate whether vaginal candidiasis is a risk factor for impaired glucose tolerance in pregnant women. Methods: A case control study of 64 pregnant women with vaginal candidiasis, positive microscopy, and 59 Candida negative control subjects, all of whom were undergoing standardized 75 g oral glucose tolerance testing between 24 and 28 weeks of their pregnancies, were enrolled. Patients were included only if they had no known diabetes mellitus or previous historic risk factors for gestational diabetes mellitus, and had not been receiving antibiotic therapy. We compared glucose levels at fasting, 30 minutes, 60 minutes and 120 minutes, and the perinatal and neonatal outcomes in the two groups. Results: There were no statistical differences between the case and control groups in terms of demographic properties. Glucose concentrations were higher in pregnant women with vaginal candidiasis than in the control subjects at fasting (89 vs. 84 mg/dL, p=0.021), 30minutes (139 vs. 126mg/dL, p=0.050), and 60 minutes (124 vs. 106 mg/dL, p=0.018) after intake of 75 g of glucose. The two groups did not differ in glucose levels 120 minutes after glucose intake. The gestational diabetes ratio was 3.1% and 3.4% in the study and control groups respectively (p=0.274). Conclusion: Tolerance to glucose in pregnant women with vaginal candidiasis seems discretely impaired.

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