Can Ramazan ONCEL, Murathan KUCUK, Mustafa UCAR, Fulya DEMİR AVCI, Aytul Belgi YİLDİRİM, Atakan YANIKOGLU

Association of Neutrophil-Lymphocyte Ratio with the Presence and Severity of Degenerative Aortic Valve Stenosis

Amaç: Farklı çalışmalarda dejeneratif aort darlığı ve aterosklerozun ortak bir patojenik mekanizmaya sahip olduğu gösterilmiştir. Bu çalışmanın amacı, NLR ile dejeneratif aort kapak darlığının varlığı ve ciddiyeti arasındaki ilişkiyi incelemekti. Gereç ve yöntemler : Kardiyoloji bölümünün ekokardiografik kayıtları ( mayıs 2011 ve eylül 2013 ) retrospektif olarak incelendi. Dışlanma kriterleri değerlendirildikten sonra 103 dejeneratif aort darlığı hastası ile normal ekokardiografik bulguları olan , yaş ve cinsiyet olarak eşleştirilmiş 35 hasta çalışmaya alındı. Bulgular : NLR seviyesi ciddi aort darlığı (AD) grubunda en yüksek bulundu. Nötrofil lenfosit oranı ciddi AD grubunda hafif ve orta aort darlığı gruplarına kıyasla daha yüksek saptandı(1,95±0,42 , 2,31±0,69 , 2,67±0,73; p< 0,001 sırasıyla).Tüm aort darlığı gruplarında NLR kontrol grubuna kıyasla yüksek saptandı.(p< 0,001). Ayrıca dejeneratif aort darlığı hastalarında transaortik pik basınç gradienti ile NLR arasında istatiksel olarak anlamlı bir korelasyon izlendi ( r : 0,626 , p < 0,001 ). Sonuç: Kronik enflamasyonun ucuz ve kolay ulaşılabilir bir göstergesi olan NLR ; dejeneratif aort darlığının varlığı ve ciddiyetini tahmin etmede kullanışlı bir rol oynayabilir.

Dejeneratif Aort Kapak Stenozu Varlığı ve Ciddiyeti ile Nötrofil-Lenfosit Oranı Arasındaki İlişki

Objective: In different studies, it has been shown that degenerative aortic stenosis and atherosclerosis had a common pathogenic mechanism. The goal of this study was to examine the association between NLR and the presence and severity of degenerative aortic valve stenosis. Methods: Echocardiographic data (from May 2011 to September 2013) of our cardiology department was reviewed retrospectively. After evaluation according to exclusion criteria's, a total of 103 patients with degenerative AS and a control group of 35 age- and gender- matched patients who had normal echocardiographic findings were included in the study. Results: The level of NLR was highest in severe AS. The neutrophillymphocyte ratio was significantly higher in severe AS group than for the mild and moderate AS group (1.95±0.42, 2.31±0.69, 2.67±0.73; p

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