Mert CEYHAN, Mustafa CEMRİ, Övsev DÖRTLEMEZ, Uğur HODOĞLUGİL, Barlas Deniz DURAKOĞLUGİL, Hakan ZENGİL, H. Michael SMOLENSKY

Ambulatory blood pressure characteristics-2: Normotensives versus hypertensives

Bu çalışmada, hipertansif hastalar ve normotansif kişilerin ambulatuar monitörler (ABPM) ile elde edilen kan basıncı profilleri ritim karakteristikleri (MESOR, doruk ve çukur değerler ile bu değerlerin ortaya çıkma zamanı, ritmik genlik, ve kan basıncı ritmindeki sabah artışının ve akşam azalışının eğimleri) açısından karşılaştırılmıştır. Bu amaçla, Gazi Üniversitesi Tıp Fakültesi Kardiyoloji ve Farmakoloji Anabilim dallarında 48 saat süreyle ABPM kayıtlan bulunan 115 normotansif ve 78 hipertansif kişinin sistolik (SBP) ve diastolik kan basıncı (DBP) profilleri kullanılmıştır. Her iki grupta da SBP ve DBP belirgin bir gün-içi ritmisite göstermiştir. Hipertansif grupta hem sistolik hem de diastolik profillerin MESOR ile doruk ve çukur değerleri normotansif gruba nazaran daha yüksek bulunmuştur. Hipertansiflerde SBP genliğinin normatansiflere nazaran daha yüksek olduğu saptanmış, ancak DBP için iki grup arasında anlamlı bir fark bulunmamıştır. ABPM kayıtlarına dayanan bilgilerin klasik ölçümlere nazaran kardiyovasküler risk hakkında daha fazla bilgi sağlayacağı ve yeni tedavi stratejileri geliştirilmesine yardımcı olacağı düşünülmektedir.

Ambulatuar basıncı özellikleri açısından normotansif ve hipertansiflerin karşılaştırılması

Purpose: Ambulatory blood pressure monitoring (ABPM) is known to be superior to a sphygmomanometer in defining the parameters of blood pressure in normotensive subjects and hypertensive patients. The aim of the present study was to compare the blood pressure characteristics in normotensive and hypertensive subjects by using ABPM devices. Methods: The recordings of 115 normotensive subjects and 78 untreated hypertensive patients, on whom ABPM was applied for 48 hours, were analyzed retrospectively. Rhythm analysis (peak, trough, MESOR, double amplitude, acrophase, bathyphase and slope values) were used to compare the ABPM measurements. Results: In both groups, SBP and DBF exhibited a clear circadian pattern with higher values during the activity period and lower values during rest. MESOR, peak and trough values of the 48-hour pattern in SBP and DBF were significantly higher in the hypertensive group than the normotensive group. The double amplitude of SBP rhythm was found to be higher in hypertensives, but DBP was not different significantly between the two groups. Conclusion: Understanding and analyzing ABPM data in hypertensive patients may help in defining limits for cardiovascular risk and also in developing efficient treatment strategies.

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