A New Low Calorie Sweetener D-Tagatose from Lactose in Cheese Whey as a Nutraceutical Value-Added Product

A New Low Calorie Sweetener D-Tagatose from Lactose in Cheese Whey as a Nutraceutical Value-Added Product

In this manuscript content, a new low calorie sweetener D-tagatose from lactose in cheese whey has been described. These research results are showing progress in improving enzymes bioconversion rate, thermos ability in increasing the half-life of the immobilized enzyme, shorting enzyme reaction time and improving both bioconversion efficiency for the hydrolysis of lactose to lactose hydrolysate (D-glucose and D-galactose) and for isomerization of D-galactose to higher yield of D-tagatose.

___

  • Beadle JR, Saunder JP, Wajada TJ. 1992. Process for manufacturing tagatose. US Patent 5,078,796. Ibrahim OO, Spradlin JE. 2000. Process for manufacturing D-tagatose. US Patent 6,057,135.
  • Bertelsen, H., Jensen, B.B. & Buemann, B.1999. D-Tagatose –a novel low-calorie bulk sweetener with prebiotic properties. World Rev. Nutr. Diet, 85: 98-109. Buemann B, Toubro S, Astrup A. 1998. D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio. J Nutr 128:1481–1486.
  • Levin, G.V., Zehner, L.R., Saunders, J.P. & Beadle, J.R.1995. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr., 62(5 Supple): 1161S-1168S.
  • Armstrong, M. Laura, Katherine J. Luecke&Leonard N. Bell. 2009. Consumer evaluation of bakery product flavour as affected by incorporating the prebiotic tagatose. International Journal of Food Science and Technology, 44, 815–819.
  • Lina B.A.R. and Kuper C.F. 2002. Chronic toxicity and carcinogenicity study with D-tagatose. TNO Nutrition and Food Research, The Netherlands, Report Number V 4533. Adachi S.1958. Formation of lactulose and tagatose from lactose in strongly heated milk. Nature 181:840–841.
  • Levin, G.V., Zehner, L.R., Saunders, J.P. & Beadle, J.R. 1995. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr., 62 (5 Supple): 1161S-1168S.
  • Hirst E.L., Hough L., and Jones J.K. N. 1949.The structure of Sterculla Setigera gum. Part 1: The investigation by the method of paper partition chromatography of the products of hydrolysis of the gum. J. chem. Soc. 3145-3151.
  • Elin S., Olarsdottir Kristine Igolfsdottir. 2001. Polysaccharide from Lichens: structural, characteristics, and biological activities. Planta Med. 67: 199-208. Marshall R., Kooi E.1957. "Enzymatic conversion of D-glucose to D-fructose". Science. 125: 648–9.
  • Nakamatu T, Yamanaka K.1969. "Crystallization and properties of L-arabinose isomerase from Lactobacillus gayonii". Biochim. Biophys. Acta.; 178 (1): 156–65. Patrick, J. & Lee, N. 1975. L-arabinose isomerase. Methods in Enzymology 41, 453-458
  • Sang-Jae Lee1,Dong-Woo Lee ,Eun-Ah Choe, Young-Ho Hong,Seong-Bo Kim, Byoung-Chan Kim and Yu-Ryang Pyun. 2005. Characterization of a Thermoacidophilic L-Arabinose Isomerase from Alicyclobacillus acidocaldarius: Appli. Environ. Microbiol. 71 (12), 7888– 7896. Manzo R.M., Simonetta A. C., Rubiolo A. C., Mammarella E. J. 2013. Screening and selection of wild strains for L-arabinose isomerase production. Braz. J. Chem. Eng . Vol. 30, No. 04, 711 – 720.
  • Yan Men, Yueming Zhu, Lili Zhang, , Zhenkui Kang, Ken Izumori,, Yuanxia Sun,, and Yanhe Ma. 2014. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5 . Microbial Research. 169, Issues 2–3, 171-178. Kim P, Yoon SH, Roh HJ, Choi JH. 2001. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Biotechnol. Prog .17: 208-210 (2001)
  • Charles Ling K.2008. Whey to ethanol: A biofuel role for cooperative? . Rural Business and Cooperative, program, Research report 214 February 2008. Douglas C. Elliott, Christopher F. wend, and Mikhail S, Alnajjar.2001; Lactose processing technology-Creating new utilization opportunities. 38th Annual Marshall Cheese seminar”tools for the trade.
  • Demaimay M., LeHenaff Y, and Printemps P. 1978. Hydrolysis of Lactose on catalytic Resin. Process Biochemistry 3-5.
  • Donner T.W, Wilber J.F., and Ostrowski D. 1999. D-tagatose a novel hexose: Acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes. Diabetes, Obesity and metabolism 1:285-29.
  • Levin G. V. 2002. Tagatose, the new GRAS sweetener and health product. J. Med Food, 5,23-36.
  • Livesey G., Brown J.C. 1996. D-tagatose is a bulk sweetener with zero energy determined in rats. J. Nutr.126, 1601-1609.
  • Food and Drug Administration (FDA). 2004. D-tagatose.
  • Johansen H.N., and Jensen B.B. 1997. Recovery of energy as SCFA after microbial fermentation of D-tagatose. Int. J. Obes. (suppl.2) 21:S50 (abs).
  • Buemann B, Toubro S, and Astrup A. 1998. Tagatose a stereoisomer of D-tagatose a stereoisomer of D-fructose, increases hydrogen production in human without affecting 24-hour energy expenditure of respiratory exchange ratio. J. Nutr. 128:1481-1486.
  • Lu Y. G. V Levin, and T.W. Donner. 2008. Tagatose, a new antidiabetic and obesitycontrol Drug, diabetes, Obesity, and Metabolism 10: 109-134.
  • Buemann B, Gesmar H., Astrup A, and Quistorff B. 2000. Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 3 PMRS. Metabolism 49:1335-1339.
  • Espinosa I., and Fogelfeld L. 2010. Tagatose; from sweetener to a new diabetic medication? Expert Opin Investig Drugs 19: 285-294. Bar A. 2000. Dossier prepared on behalf of Arla Food ingredients amba, Viby, Denmark for safety assessment of D-tagatose by a panel of independent experts. Cited in GRN 000078.
  • Food and Drug Administration (FDA). 2003. Food labeling. Health claims. D-tagatose and dental caries. Final rule. Fed Reg. .68:39831-39833. Bar A. 2004. Tagatose: Food Scientific Regulatory Service. Bioresco.
  • Buemann B., Toubro S., Holst J. J., Rehfeld J., and Astrup A. 1999. D-tagatose stereoisomer of D-fructose , increases blood uric acid concentration . Metabolism 49: 969-976.
  • Marta W., and Jozef K. 2012. A method for the production of D-tagatose a recombinant Pichia pastoris strain secreting B-DD-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp.22cMicrob.Cell Fact. 11-13.
  • Yan Men, Yueming Zhu, Lili Zhang, , Zhenkui Kang, Ken Izumori,, Yuanxia Sun,, and Yanhe Ma. 2014. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5 . Microbial Research. 169, 2–3, 171-178.
  • Kim P, Yoon SH, Roh HJ, Choi JH. 2001. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Biotechnol. 17, 208-210.