Effects of Flunixine Meglumine, Diclofenac Sodium, Metamizol Sodium and Carprofen on Oxidative Stress in Rats Subjected to Laparotomy

Bu çalışmada laparatomi uygulanan ratlarda bazı nonsteroid antiinflamatuar grubu ilaçların oksidatif stres üzerine etkilerinin belirlenmesi amaçlandı. Ratlar (n=50) 5 eşit gruba ayrıldı. Kontrol grubuna (Grup I) serum fizyolojik verilirken, diğer Grup II-IV' e sırasıyla metamizol 50 mg/kg (II), flunixin meglumin 2.5 mg/kg (III), carprofen 2.5 mg/kg (IV) ve diklofenak sodium 2.5 mg/kg (V) intraperitoneal 5 gün süreyle enjekte edildi. Postoperatif 6. günde kan örnekleri alınarak serum malondialdehit (MDA) ve nitrik oksit (NO) düzeyleri ve eritrosit glutatyon (GSH) ve katalaz seviyeleri belirlendi. NSAID grubu ilaçlar MDA, NO ve GSH seviyesinde bir azalmaya neden olurken, katalaz seviyesinde artışa yol açtı. Sonuç olarak NSAID grubu ilaçların anti-inflamatuar etkilerine ek olarak değişik yollardan oksidatif stresi azaltabilirler.

Laparotomi Uygulanan Ratlarda Oksidatif Stres Üzerine Fluniksin Meglumin, Diklofenak Sodyum, Metamizol Sodyum ve Karprofenin Etkileri

The aim of this study was to determine the effects of nonsteroid antiinflammatory drugs on oxidative stress in rats subjected to laparotomy. Rats (n=50) were divided into five equal groups. Control group (n=10, Group I) received physiological saline whereas Groups II-V (n=10 in each) received metamizole (50 mg/kg), flunixin meglumine (2.5 mg/kg), carprofen (2.5 mg/kg), or diclofenac (2.5 mg/kg) by intraperitoneal injection for 5 days following the operation. On postoperative day 6, blood samples were obtained; levels of malondialdehyde (MDA) and nitric oxide (NO) in serum, and erythrocyte glutathione (GSH), catalase levels were determined. NSAIDs caused a decrease in MDA, NO and GSH levels, whereas catalase levels increased with NSAID treatment. In conclusion, NSAIDs may have additional beneficial effects to their anti-inflammatory effects by diminishing the oxidative stress.

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