Dinç EŞSİZ, İsmail KUTLU, Hakan SALTAŞ, Gökhan ERASLAN, Ali BİLGİLİ

Farelerde klorprifos ve diklorvos' un humoral immun yanıt üzerine etkisi

Çalışmada, belirli süre (28 gün) ve dozlarda verilen organik fosforlu insektisit klorprifos ve diklorvosun (klorprifos 10, 20, 40 ve 80 mg/kg/ca/gün; diklorvos 30, 60 mg/kg/ca/gün) humoral bağışıklık üzerine etkisi araştırılmıştır. Bunun için 3 aylık, Swiss Albino ırkı, erkek, 80 adet fare kullanılmıştır. Fareler, çalışmanın l. ve 15. gününde ölü S. thyphi ile periton içi olarak immunize edilmiştir. Takiben 13. (birinci dönem) ve 28. (ikinci dönem) günlerde kan alınmış ve antikor titreleri değerlendirilmiştir. Sonuçta, içme suyu ile birinci dönemde, 80 mg/kg.ca/gün klorpirifos, ikinci dönemde 40 ve 80 mg/kg.ca/gün klorprifos ile 60 mg/kg.ca/gün diklorvos verilen grupların humoral bağışıklık sisteminde anlamlı (p

The effect of chlorpyrifos and dichlorvos on humoral immune response in mice

In this study, the effects of chlorpyrifos and dichlorvos that are organic phosphorous insecticides were investigated on humoral immune system during 28 days (chlorphyrifos at 10, 20, 40 and 80 mg/kg/bw/day, dichlorvos at 30, 60 mg/kg/bw/day). For this aim, a total of 80, Swiss Albino race, male, three-months-old mice were used. Mice were immunized with S. thy phi intraperitonally at the 1st and 15th day of experiment. Following that, on 13th (primary period) and 28th (secondary period) days, blood samples were taken and antibody liters were evaluated. As a result, statistically significant (p

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