Maşallah CANDEMİR, Özmert Muhammet Ali ÖZDEMİR, Hacer ERGİN

Bir Vaka Nedeniyle Selim Geçici Hiperfosfatazemi

Selim geçici hiperfosfatazemi küçük çocuklarda, serum alkalen fosfataz düzeyinin normalin 3-50 katı yüksekliği ile karakterizedir. Nedeni tam olarak bilinmemekle birlikte birçok viral enfeksiyonla ilişkili olduğu saptanmıştır. Alkalen fosfataz düzeyleri 2-6 ay içinde kendiliğinden normale dönmektedir. Bu yazıda akut gastroenterit atağı nedeniyle tetkik edilirken serum alkalen fosfataz yüksekliği (3755 UI/L) saptanan, karaciğer ve kemikle ilgili eşlik eden bir patoloji bulunamayan, klinik takibinin 3. ayında ALP düzeyleri kendiliğinden normale gerileyen 19 aylık bir olgu sunulmuştur.©2008, Fırat Üniversitesi, Tıp Fakültesi

Anahtar Kelimeler:

Selim geçici hiperfosfatazemi, serum alkalen fosfataz

A Case of Benign Transient Hyperphosphatasemia

Benign transient hyperphosphatasemia is characterised by high serum alkaline phosphatase levels which is seen early childhood. The etiology is unknown but can be relation many viral infections. The high alkaline phosphatase levels turn normal in 2-6 months. This article presents a patient of 19 months old boy whose levels of alkaline phosphatase were found 3755 UI/L after acut gastroenteritis. The patologies of related bone or liver not found. Later the high alkaline phosphatase levels turn to normal spontaneously in 3 months. ©2008, Firat University, Medical Faculty.

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Suzuki M, Okazaki T, Nagai T, Toro K, Setonyi P. Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol. 2002; 33: 215-218.
Garty BZ, Nitzan M. Benign transient hyperphosphatasemia. Isr J Med Sci. 1994; 30: 66-69.
Tolaymat N, de Melo MC. Benign transient hyperphosphatasemia of infancy and childhood. South Med J. 2000; 93: 1162-1164. Griffiths J, Vernocchi A, hyperphosphatasemia of infancy and childhood. A study of serum alkaline phosphatase by electrofocusing techniques. Arch Pathol Lab Med. 1995; 119: 784-789. Simoni E. Transient
Posen S, Kilhan H, Latham S, Lee R, Keefe JF. Transient hyperphosphatasemia of infancy an insufciently recognized syndrome. Clin. Chem. 1977; 23: 292-294.
Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child. 1985; 139: 740.
Nicholson JF, Pesce MA. Reference ranges for laboratory tests and procedures. In: Behrman RE, Kliegman RM, JJenson HB, eds. Nelson Textbook of Pediatrics (17 th edition), WB Saunders Company, Philadelphia, USA. 2004: 2396-2427.
Behulova D, Bzduch V, Holesova D, Vasilenkova A, Ponec J. Transient hyperphosphatasemia of infancy and childhood: study of cases. Clin Chem. 2000; 46: 1868-1869. Ranchin B, Villard F, Andre hyperphosphatasemia after organ transplantation in children.
Pediatr Transplant. 2002; 6: 308-312. JL et al. Transient
Kikuchi S, Fujikawa S, Hara K, Ohira M, Kojima C, Maekawa M. Transient hyperphosphatasemia observed in a boy with acute lymphoblastic leukemia. Rinsho Byori. 1997; 45: 795-800.
Chesney WR. Metabolic bone disease. In: Behrman RE, Kliegman RM, JJenson HB, eds. Nelson Textbook of Pediatrics (17 th edition), WB Saunders Company, Philadelphia, USA. 2004: 2341
Dündar B, Türedi A, Çomak E. Selim geçici hiperfosfatazemili bir vaka. Çocuk dergisi. 2005; 5: 66-67 Kabul Tarihi:27.09.2007