Ortalama Eritrosit Hacmi Düzeyinin Alkolik Karaciğer Sirozu Tanısındaki Yerinin Belirlenmesi ve Prognoza Etkisinin İrdelenmesi

Amaç: Alkolik karaciğer sirozunda(AKS) makrositoz sıklığı ve makrositoz ile prognoz arasındaki ilişkinin belirlenerek doğruluk, duyarlılık ve özgüllük değerlerinin tespiti amaçlanmıştır. Gereç ve Yöntem: AKS tanısı olan toplam 46 hasta(grup 1)ile Hepatit B ve C virüslerine bağlı karaciğer sirozu (KS)tanısı olan 51 hastanın(grup 2) ortalama eritrosit hacmi(OEH) düzeyleri retrospektif olarak karşılaştırıldı. Bulgular: Grup 1'de OEH değeri 94.6±10.87 olup, grup 2 hastalardan anlamlı olarak yüksek saptandı(p

Anahtar Kelimeler:

Siroz, alkol, makrositoz, prognoz

Determination of the Role of Mean Corpuscular Volume Level on the Diagnosis of Alcoholic Liver Cirrhosis and Investigation of Its Effect on the Prognosis

Objectives: In this study, we aimed to determine the relationship between macrocytosis and Alcoholic Liver Cirrhosis (ALC) and its accuracy, sensitivity and specificity rates. Material and Methods: Mean corpuscular volume (MCV) levels of 46 patients diagnosed as having ALC (Group 1) and 51 patients diagnosed as having Hepatitis B cirrhosis and Hepatitis C cirrhosis (Group 2) were compared retrospectively. Results: MCV level determined as 94.6±10.87 in patients in Group 1 was statistically significantly higher than in patients in Group 2 (p

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Rutherford CJ, Frenkel PF. Hemostatic disorders in liver disease. In:Schiff ER, Sorrell MF, Maddrey WC (Editors). Schiff’s Diseases of the Liver. 8. edition , Philedelphia-New York: Lippincott-Raven Publishers, 1999: 583-598
Pasqualetti P, Festuccia V, MacCarone C, DiLaura G, Casale R. Diagnostic value of gamma glutamyl transpeptidase and the mean corpusculer volume in chronic hepatitis of alcoholic etiology. Minerva Med 1995; 86: 395-402
Soysal T. Megaloblastic Anemias. In: Soysal T, Soycan LY (Editors). Continuous Medical Education Symposium Serial of Cerrahpasa Medical Faculty of Istanbul University. Istanbul: Kaya Publishers, 2001: 33-47
Mates M, Heyd J, Soununjon M et all. The haematologist as watcdog of community health by full blood count. QJM 1995; 88: 333-339
Riedler GF, Zollinger P, Schmid M. Changes in the blood picture in liver diseases. Schweiz Med Wochenshr 1975; 105: 1593
Intragumtornchai T, Rojnukkarin Vajanamarhutue C, Israsena S. Anemias in Thai patients with cirrhosis. Int J Hematol(Ireland) 1997; 65: 365-373 P, Swasdikul D,
Maruyama S, Hirayama C, Yamamato et all. Red blood cell status in alcoholic and non-alcoholic liver diseases. J Lab Med 2001: 138: 332-337
Sherlock S, Dooley J. Alcohol and liver. In:Sherlock S, Dooley J (Editors). Diseases of the liver and biliary system. 10. baskı, Oxford: Blackwell Science Ltd, 1997: 385-400
Wu A, Chanarin I, Slavin G, Levi AJ. Folate deficiency in the alcoholics-its relationship to clinical and haematological abnormalities, liver disease and folate stores. Br Haematol 1975; 29: 469-478
Seppa K, Sillanaukee P. Women, alcohol and red cells. Alcohol Clin Exp Res. 1994: 18: 1168-1171
Oski FA. Anemia due to other nutritional deficiencies. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ (Editors). Williams Hematology. 5. baskı, McGraw Hill Health Professions Division International Edition, 1995: 511-514
Balcells A, Ingelmo M, Vivancos J et all. Macrocytosis in chronic alcoholism (author’s transl). Med Clin (barc) 1979; 73 :312-314
Gheno G, Magnabosco V, Mazzei G. Macrocytosis and anemia in chronic alcoholism. Correlation with the results of hepatic needle biopsy. Minerva Med 1981; 72: 1301-1306
Yersin B, Nicolet JF, Dercy et all. Screening for excessive alcohol drinking; comparative value of carbohaydrate deficient transferin, gamma glutamyl transpeptidase and mean corpuscular volume. Arch Intern Med 1995; 155: 1907-1911
Sun L, Konig IR, Jacobs A, et al. Mean corpuscular volume and ADH1C genotype in white patients with alcohol-associated diseases. Alcohol Clin Exp Res 2005;29:788-93
Kabul Tarihi: 02.11.2007