İSMAİL DEMİREL, Levent AVCI, Güneri ATALAN, AYKUT URFALIOĞLU, Gonca TOPRAK ÇAĞLAR

Antifriz içen bir hastada etilenglikol zehirlenmesi: Olgu sunumu

Etilenglikol (EG) zehirlenmesi ülkemizde çok nadir rastlanan zehirlenmelerdendir. EG, dihidrik alkoller grubundan, renksiz, kokusuz, tatlı ve suda çözünen bir maddedir. Kaza yada suisid amaçlı olarak alınması sonucu, şiddetli metabolik asidoz, santral sinir sistemi depresyonu ve akut böbrek yetmezliği ile giden zehirlenme tablosu ortaya çıkar. Suisid amaçlı antifriz içtikten sonra EG zehirlenmesine bağlı olarak ağır metabolik asidoz, koma ve akut böbrek yetmezliği tablosu gelişmiş bir olguyu sunduk.

Ethyleneglycol intoxication in a patient drunk antifreeze: A case report

Ethyleneglycol (EG) poisoning is a very rare type of intoxication in our country. EG belongs to the group of dihydric alcohol, a colourless, odourless, sweet tasting fluid. Intake of EG, either accidentally or suicide attempt, is characterised by severe metabolic acidosis, depression of central nervous system and acute renal failure. We reported here a case with severe metabolic acidosis, coma and acute renal failure due to suicidal intake of EG.

PDF

___

1. Linden CH, Lovejoy FH. Poisoning and drug overdosage. In: Fauci A, Braunwald E, Isselbacher K, Wilson J, Martin J (eds). Harrison's Principles of Internal Medicine. 14th ed. New York: The McGraw- Hill Companies, 1998; 2534-35.
2. Robertson WO. Common poisoning. In: Wyngaarden JB, Smith LH, Bennett JC (eds). Cecil Textbook of Medicine. 19th ed., Philadelphia: W. B. Saunders Company, 1992; 113.
3. Schauben J. Methanol and ethylene glycol toxicity. US Pharmacist 1998; 23: 22-3.
4. Barceloux DG, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol 1999; 37: 537-60.
5. Davis DP, Bramwell KJ, Hamilton RS, Williams SR. Ethylene glycol poisoning: case report of a record-high level and a review. J Emerg Med 1997; 15: 653-67.
6. Zimina LN, Budarina IS, Nazarenko AF. Morphologic changes in the liver and kidney in ethyleneglycol poisoning. Arkh Patol 1977; 39: 51-8.
7. Khan SR, Glenton PA, Byer KJ. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hy- peroxaluria by hydroxy-L-proline. Kidney Int 2006; 70: 914- 23.
8. Kaiser N, Reiger I, Foidl E, Berek K, Baumgartl P. Ethyleneglicol intoxication in a dipsomaniac patient. Nephrol Dial Transplant 1997; 12: 1753-4.
9. Gallyas F, Jaray J, Csata S. Acute renal failure following ethyleneglycol poisoning. Report of three successfully treated cases. Acta Chir Acad Sci Hung 1971; 12: 225-8.
10. Jabobsen D, McMartin KE. Antidotes for methanol and ethylene glycol poisoning. J Toxicol 1997; 35: 127-43.
11. Hall TL. Fomepizole in the treatment of ethylene glycol poisoning. CJEM 2002; 49: 130-7.
12. Frommer JP, Ayus JC. Acute ethylene glycol intoxication. Am J Nephrol 1982; 2: 1-5.