Mezenkimal Kök Hücrelerin Meme Kanseri Tedavisinde Güncel Katkıları

Mezenkimal kök hücreler (MKH) erişkin dokulardan elde edilen pluripotent kök hücrelerdir.Mezenki-mal kök hücrelerin plastisite, farklılaşabilme, immünmodülatör aktiviteleri onları dokurejenerasyonu, hedefli ilaç taşıma, yara iyileşmesi ve kanser gibi birçok alanda araştırılmayasevketmiştir. MKH’lerin, yarada olduğu gibi salgıladıkları enflamatuar ve sitokin benzerliklerisebebiyle kanserde de tümörlü ve metastatik bölgeye migrasyonu ve tropizmi olduğu bilinmektedir.Ancak literatürde MKH’lerin tümörogenezi arttırdığına veya azalttığına dair çelişen bilgilermevcuttur. MKH’lerin immünmodülatör özel-likleri ile kanser hücrelerine karşı immün baskılayıcıolabildikleri gibi immün arttırıcı da olabildikleri bilinmektedir. Meme kanserinde MKH’lerin terapötikpotansiyeli ise birçok kaynak tarafından destek-lenmektedir. Biz bu eleştiri yazımızda mezenkimalkök hücrelerin meme kanseri progresyonu üzerinde etkilerini ve tedavi mekanizmalarını güncel bilgiile özetleyeceğiz.

Mezenkimal Kök Hücrelerin Meme Kanseri Tedavisinde Güncel Katkıları

Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from adult tissues. The plasticityof mesenchymal stem cells, differentiation, immunomodulatory activities have led them toinvestigate in many areas such as tissue regeneration, target drug delivery, wound healing andcancer. MSCs migrate to the region and have tropic and penetrate the tumor and metastatic regionsto remove the bladder. However, in the literature there is information on the extent to which MSCsincrease or decrease tumorigenesis. It is known that MSCs can be immunosuppressants againstcancer cells as well as immunostimulants with their immunomodulatory properties. The therapeuticpotential of MDRs in breast cancer is supported by a wide variety of sources. We will summarize theinteraction and treatment mechanisms of mesenchymal stem cells on breast cancer progression withcurrent knowledge.

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