DİŞ GELİŞİMİNE MOLEKÜLER, GENETİK VE HİSTOLOJİK YAKLAŞIM

Memeli dişlenme dönemi, farklı bir yapıda gelişmektedir. Ön bölgeden arka bölgeye doğru diş dizisinde, kesici, kanin, küçük azı ve büyük azı diş çeşitleri yer almaktadır. Bu derleme, diş gelişimi ile birlikte, dişe şeklini veren diğer dokuların oluşumunu histolojik olarak ele almaktadır. Bunun yanında, morfogenezisi daha iyi anlayabilmek için, hücre gelişimi ve hücresel migrasyon da dahil, hücrelerin diferansiyasyon mekanizmaları da ele alınmalıdır. Ekstremite, böbrek veya diş gibi gelişmekte olan neredeyse her yapıda, birçok gen ekspresyonu, ardarda gelmekte ve bu mekanizma hücrelerin doğru zamanda doğru yerde olmasını, hücresel diferansiyasyonun doğru bir biçimde meydana gelmesini sağlamaktadır. Diş gelişiminde yüzlerce gen ekspresyonu görülmekte ancak bu derleme şimdiye kadar açıklanabilen en önemli sinyal moleküllerini kapsamaktadır.

Anahtar Kelimeler:

Diş germi, odontogenezis

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Mammalian dentition consist of teeth that develop as discrete organs. From anterior to posterior, the dentition is divided into regions of incisor, canine, premolar and molar tooth types. This rewiev discusses the histologic aspect of tooth development and the coming together of the different tissues that give rise to the form and give shape to the tooth. However, to better understand ‘morphogenesis’, the molecular signals that control cell growth, migration, and ultimately cell fate and differantiation also must be considered. For every developmental event, whether of limb, kidney, or tooth, a complex and intricate cascade of gene expression takes place to direct the cells to the right place and onto the proper differantiation pathway. Hundreads of genes likely are expressed for each developmental pathway, but this rewiev covers the most important signaling molecules and pathways so far described

Keywords:

Tooth germ, odontogenesis,

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