Günay ÖNAL, Abdulkadir LEVENT, Zühre ŞENTÜRK

Electroanalytical Investigation of Cancer Chemotherapy Drug Vinorelbine On Disposable Pencil Graphite Electrode in Surfactant Media by Voltametric Method

One of the biggest global public health issues, cancer has a negative impact on people's health and quality of life. Therefore, it is undeniable that the interest in drugs for cancer treatment has increased. On the other hand, in addition to patient safety during the administration of drugs used in cancer treatment due to their possible toxic properties, it is crucial to maintain a safe working environment and to safeguard the health professionals who provide the treatment from the possibility of coming into touch with this class of medications. At the same time, it is extremely important to develop methods for the analysis of antineoplastic drugs in different environments. In this study, a new application of disposable pencil-tip graphite electrode for the determination of Vinorelbine, which is one of the semi-synthetic derivatives of Vinca alkaloids, which is in the class of herbal antineoplastic drugs used in cancer treatment, is presented. Using a pencil-tip graphite electrode, the CV and SWV techniques were used to examine the electrochemical characteristics of vinorelbine throughout a large pH range (2.0-12.0), both without and with surfactant medium. Vinorelbine in BR (pH=10.0) buffer containing 3 mM cationic surfactant (tetra-n-butylammonium bromide) by SW-AdSV technique, it responded voltammetrically with a potential of +0.75 V. The suggested technique has been used successfully with human urine samples that have been spiked with vinorelbine and medication formulations.

Keywords:

Pencil graphite electrode Square-wave adsorptive stripping voltammetry, cationic surfactant, Vinorelbine,

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