Bahadır KIRALİ, Kübra KUNDAK, Basak DOGAN, Leyla KURU

Evre 3 Derece B Periodontitis Hastalarında Başlangıç Periodontal Tedavinin Tükürük IL-6 ve IL-17 Seviyelerine Etkisi

Amaç Bu çalışmada Evre 3 Sınıf B periodontitis hastalarında başlangıç periodontal tedavinin klinik parametreler ve tükürük interlökin (IL)-6 ve IL-17 seviyelerine etkisini belirlemek amaçlandı. Gereç ve Yöntem Çalışma popülasyonunu sistemik sağlıklı, 10 periodontal sağlıklı ve 10 Evre 3 Sınıf B periodontitisli olmak üzere 20 birey oluşturdu. Tüm ağız plak indeks, gingival indeks, sondalama derinliği, sondalamada kanama ve klinik ataşman seviyesi tedavi öncesi ve 3 ay sonrası kaydedildi. Periodontitis grubuna 4 seans başlangıç periodontal tedavi uygulandı. Periodontitisli gruptan tedavi öncesi ve sonrası 3. ayda olmak üzere 2 kez, sağlıklı gruptan ise 1 kez tükürük örnekleri alındı. Bu örneklerdeki IL-6 ve IL-17 seviyeleri sandwich Enzyme-Linked Immunosorbent Assay (ELISA) yöntemi ile tespit edildi. Bulgular Evre 3 Sınıf B periodontitis hastalarının başlangıç klinik parametreleri sağlıklı gruba göre istatistiksel anlamlı yüksek bulundu (p0,05). Periodontitisli hastaların tedavi sonrası tüm parametrelerinde istatistiksel olarak anlamlı azalma görüldü (p0,05). Periodontitisli hastaların başlangıç tükürük IL-6 ve IL-17 seviyeleri sağlıklı gruba göre anlamlı derecede yüksek (p0,05) tespit edilirken, tedavi sonrasında her iki biyobelirteç seviyesinde anlamlı azalma görüldü (p0,05). Sonuç Periodontitis hastalarında sağlıklı bireylere göre yüksek tespit edilen tükürük IL-6 ve IL-17 seviyesinin başlangıç periodontal tedavinin olumlu etkisiyle azalması, bu pro-enflamatuvar sitokinlerin periodontal hastalık belirteci olarak kullanılabileceğini düşündürmektedir.

Anahtar Kelimeler:

IL-6, IL-17, periodontitis, tükürük

The Effect of Initial Periodontal Treatment on Salivary IL-6 and IL-17 Levels in Stage 3 Grade B Periodontitis Patients

Aim The aim of this study is to establish the effect of initial periodontal treatment on salivary interleukin (IL)-6 and IL-17 levels in Stage 3 Grade B periodontitis patients. Materials and Methods The study population consisted of systemically healthy, 10 periodontally healthy and 10 Stage 3 Grade B periodontitis individuals. Plaque index, gingival index, probing depth, bleeding on probing and clinical attachment levels were recorded before and 3 months after the treatment. Four sessions of initial periodontal treatment was performed to periodontitis patients. Saliva samples were collected before and 3 months after treatment from periodontitis patients and once from healthy group. Salivary IL-6 and IL-17 levels were determined by ELISA. Results At the beginning all clinical parameters were statistically higher in periodontitis group than the healthy group (p0,05). All of the clinical parameters are decreased significantly after treatment in periodontitis group (p0,05). There was a statistically significant decrease in IL-6 and IL-17 level after treatment in Stage 3 Grade B periodontitis group (p0,05). Conclusion The levels of salivary IL-6 and IL-17 which are higher in periodontitis group than healthy individuals decrease by the positive effects of initial periodontal treatment. This finding suggests that IL-6 and IL-17 can be used as markers for periodontal disease.

Keywords:

IL-6, IL-17, periodontitis, saliva,

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