Significant Alteration of Nitrogen Species in Acute Myocardial Infarction does not Relate to the Site of Infarction

Bu çalışmada akut miyokard infarktüsü ile başvuran hastalarda seviyesini ve enfarktüs bölgesi ile nitrojen türlerinin ilişkisi değerlendirmek amaçlanmıştır. Diyala Eğitim Hastanesi'nde yoğun bakım ünitesine başvuran 113 hasta çalışmaya alındı . Hastalar ağrı başlangıcından ilk 6 saat içinde sunulan elektrokardiyografi kriterleri ve pozitif troponin testi ile akut miyokard infarktüsü tanısı konuldu. En yaygın enfarktüs bölgesi anteriyor, inferiyor ve lateral idi. Serum peroksinitritlerin seviyesi 100 kez sağlıklı kontrol grubuna göre daha yüksekti. Serum nitrik oksit düzeyi %50 oranında sağlıklı bireylerle karşılaştırıldığında zalmıştı. Enfarktüs bölgelerine göre nitrojen türlerinin anlamlı olmayan farklılıklar vardı. Hipertansiyon, diabetes mellitus ve sigara gibi ilişkili risk faktörleri nitrojen türlerinin düzeylerini etkilemiştir. Bu azot türlerindeki değişiklikler akut enfarktüs bölgesi ile ilgili olmadığı sonucuna varılmıştır

Anahtar Kelimeler:

Akut miyokard infarktüsü, nitrik oksit, peroksinitrit

Significant Alteration of Nitrogen Species in Acute Myocardial Infarction does not Relate to the Site of Infarction

This study aimed to assess the level of nitrogen species in patients presented with acute myocardial infarction and to relate the levels of nitrogen species to the infarction site. A total number of 113 patients admitted to the intensive care unit at Diyala Teaching Hospital. The patients were presented within 6 hours of pain onset and diagnosed as acute myocardial infarction using electrocardiograph criteria and positive cardiac troponin test. The most common infarction site was anterior followed by inferior and lateral. Serum peroxynitrite level was significantly higher than healthy subjects by 100 folds and serum nitric oxide level is significantly reduced compared with healthy subjects by 50%. There were non significant differences in nitrogen species regarding the infarct sites. Associated risk factors e.g. hypertension, diabetes mellitus and smoking influenced the nitrogen species levels. It concludes that the significant alterations in nitrogen species not related to the site of acute infarction

Keywords:

Acute myocardial infarction, nitric oxide, peroxynitrite,

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