Condylar Hyperplasia: Case Report and Literature Review
Condylar Hyperplasia: Case Report and Literature Review
Introduction
The condition characterized through excessive growth of the mandible on the condyle and neck is called condylar hyperplasia
(CH).It is considered as an uncommon malformation. Although the reason of this condition is not known exactly, some etiological
factors have been suggested.These factors are; endocrinal disorders, trauma and local circulatory disorders. When CH is evaluated
clinically, some symptoms such as facial asymmetry, prognathism, crossbite and open bite appear. While the acceleration of
growth in one of the two developing condyles in adolescence period may cause this condition, another reason is enlargement of
the condyle after stopping of skeletal growth. CH should be differentiated from structures such as osteochondroma and osteoma.
During this distinction, the method such as scintigraphy is used in addition to histopathological and radiographic evaluations.
Materials and Methods
An observational study was used to create this report. Journal of Oral and Maxillofacial Surgery, International Journal of Oral
and Maxillofacial Surgery, and Journal of Craniomaxillofacial Surgery publications that were available through to the PubMed
database were included in the study.
Results
CH consists of a comprehensive examination and diagnostic methods for correct treatment. Patients often apply for treatment
because of facial asymmetry and related aesthetic problems. Additional research is needed to compose a more standardized
approach to diagnose CH activity
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- 1. Güreser G, Temporomandıbular joınt dısorders. The Eur J
of Med. 2003;6(2):37–45.
- 2. Giray B, Aktaş A. Yetişkin hastada kondiler hiperplazi. J
Hacettepe Faculty of Dent. 2008;32 (3):45-50.
- 3. Hernáandez-Alfaro F, Escuder Ò. Joint formation between
an osteochondroma of the coronoid process and the
zygomatic arch (Jacob disease): report of case and review
of literature.J of oral maxillofacial surg.2000;58(2):227-32.
- 4. Costa YM, Porporatti AL, Stuginski-Barbosa J. Coronoid
process hyperplasia: an unusual cause of mandibular
hypomobility. Braz Dent J. 2012;23(3):252–5.
- 5. McLoughlin P, Hopper C. Hyperplasia of the mandibular
coronoid process: an analysis of 31 cases and a review of the
literature.J of oral and maxillofacial surg.1995;53(3):250-5.
- 6. Kim S, Lee J, Kim H. Mouth opening limitation caused
by coronoid hyperplasia: a report of four cases. J of the
Korean Association of Oral and Maxillofacial Surg 2014;
40(6): 301-7.
- 7. Raijmakers PG, Karssemakers LHE, Tuinzing DB. Female
predominance and effect of gender on unilateral condylar
hyperplasia: A review and meta-analysis. J Oral Maxillofac
Surg. 2012;70(1).
- 8. Shetty S.Case Report: unilateral condylar hyperplasia.
F1000Research 2021;10:46.
- 9. Nitzan D, Katsnelson A, Bermanis I. The clinical
characteristics of condylar hyperplasia: experience with 61
patients.Joms.2007;66(2):312-8.
- 10. Almeida L, Zacharias J, Pierce S. Condylar hyperplasia: An
updated review of the literature. Korean J of Orthodontics
2015; 45(6): 333-40.
- 11. Wolford L, Movahed R. A classification system for conditions
causing condylar hyperplasia. J of oral and maxillofacial
surg.2014;72(3):567-95.
- 12. Obwegeser H, Makek M. Hemimandibular hyperplasiahemimandibular
elongation.J of maxillofacial
surg.1986;14:183-208.
- 13. Bruce R, Hayward J. Condylar hyperplasia and mandibular
asymmetry: a review.J Oral Surg.1968;24(4):281-90.
- 14. Larry M.Wolford, PushkarMehra. Efficacy of high
condylectomy for management of condylar hyperplasia.
Am J Orthod Dentofac Orthop. 2002;121(2):136–51.
- 15. Slootweg P, Müller H. Condylar hyperplasia. A clinicopathological
analysis of 22 cases. J maxillofacial
surg.1986;14:209-214.
- 16. Muñoz MF, Monje F, Goizueta C, Rodríguez-Campo F.
Active condylar hyperplasia treated by high condylectomy:
Report of case. J Oral Maxillofac Surg. 1999;57(12):1455–9.
- 17. Gray R, Sloan P, Quayle A. Histopathological and
scintigraphic features of condylar hyperplasia. Int j oral
and maxillofacial surg.1990;19(2):65-71.
- 18. Tatlı D, Keles B.Unilateral kondiler hiperplazinin konik
ışınlı bilgisayarlı tomografi ile değerlendirilmesi:iki olgu
sunumu ve literatür derlemesi. J Dent Fac Ataturk Univ.
Page 76
2010;3:198-204
- 19. Hansson T, Öberg T, Carlsson GE, Kopp S. Thickness
of the soft tissue layers and the articular disk in
the temporomandibular joint. Acta Odontol Scand.
1977;35(1):77–83.
- 20. Chen Y, Ke J, Long X, Meng Q. Insulin-like growth factor-1
boosts the developing process of condylar hyperplasia by
stimulating chondrocytes proliferation.Osteoarthritis and
cartilage. 2012;20(4):279-87.
- 21. Saridin CP, Raijmakers PGHM, Kloet RW, Tuinzing DB,
Becking AG, Lammertsma AA. No Signs of Metabolic
Hyperactivity in Patients With Unilateral Condylar
Hyperactivity: An In Vivo Positron Emission Tomography
Study. J Oral Maxillofac Surg. 2009;67(3):576–81.
- 22. Li QF, Rabie ABM. A new approach to control condylar
growth by regulating angiogenesis. Arch Oral Biol.
2007;52(11):1009–17.
- 23. Talwar RM, Wong BS, Svoboda K, Harper RP. Effects
of Estrogen on Chondrocyte Proliferation and Collagen
Synthesis in Skeletally Mature Articular Cartilage. J Oral
Maxillofac Surg. 2006;64(4):600–9.
- 24. Yu S, Xing X, Liang S, Ma Z, Li F, Wang M, et al. Locally
synthesized estrogen plays an important role in the
development of TMD. Med Hypotheses. 2009;72(6):720–2.
- 25. Hodder SC, Rees JIS, Oliver TB. SPECT bone scintigraphy
in the diagnosis and management of mandibular condylar
hyperplasia. Br J Oral Maxillofac Surg. 2000;38(2):87–93.
- 26. Lopez B, Corral S. Condylar hyperplasıa: characterıstıcs,
manıfestatıons, dıagnosıs and treatment. a topıc revıew.
Rev Fac Odontol Univ Antioquia. 2015;26(2):425–46.
- 27. Trıpathı T, Srıvastava D. Differential Diagnosis and
Treatment of Condylar Hyperplasia. J Clin Orthod. 2019.
- 28. Valente L, Tieghi R, Mandrioli S, Galiè M. Mandibular
Condyle Osteoma. Ann Maxillofac Surg. 2019;9(2):434.
- 29. Ito FA, De Andrade CR, Vargas PA, Jorge J, Lopes
MA. Primary tuberculosis of the oral cavity. Oral Dis.
2005;11(1):50–3.
- 30. Pripatnanont P, Vittayakittipong P, Markmanee U. The use
of SPECT to evaluate growth cessation of the mandible in
unilateral condylar hyperplasia. Int J Oral Maxillofac Surg.
2005;34(4):364–8.
- 31. Bilgili E. Investigation of Unilateral Mandibular Coronoid
Hyperplasia Cases Using Cone Beam Computed
Tomography. Van Med J. 2017.
- 32. Kubota Y, Takenoshita Y, Takamori K. Levandoski
panographic analysis in the diagnosis of hyperplasia
of the coronoid process. Br J Oral Maxillofac Surg.
1999;37(5):409–11.
- 33. Tavassol F, Spalthoff S, Essig H.Elongated coronoid
process: CT-based quantitative analysis of the coronoid
process and review of literature. Int J Oral Maxillofac Surg.
2012;41(3):331–8.
- 34. Kaban LB, Cisneros GJ, Heyman S. Assessment of
mandibular growth by skeletal scintigraphy. J Oral
Maxillofac Surg. 1982;40(1):18–22.
- 35. Alyamani A, Abuzinada S. Management of patients with
condylar hyperplasia: A diverse experience with 18 patients.
Ann Maxillofac Surg. 2012;2(1):17.
- 36. Yang Z, Reed T, Longino BH. Bone Scintigraphy SPECT/
CT Evaluation of Mandibular Condylar Hyperplasia. J Nucl
Med Technol. 2016;44(1):49–51.
- 37. Sreeramaneni SK, Chakravarthi PS, Krishna Prasad L.
Jacob’s disease: report of a rare case and literature review.
Int J Oral Maxillofac Surg. 2011;40(7):753–7.
- 38. S Sembronio, A Tel, F Costa MR. An updated protocol for
the treatment of condylar hyperplasia: computer-guided
proportional condylectomy. J Oral Maxillofac. 2019
.
39. B.Naini F, A.Donaldson AN. Assessing the influence of
asymmeftry affecting the mandible and chin point on
perceived attractiveness in the orthognathic patient,
clinician, and layperson. J Oral Maxillofac Surg.
2012;70(1):192–206.
- 40. Motamedi MHK. Treatment of condylar hyperplasia of
the mandible using unilateral ramus osteotomies. J Oral
Maxillofac Surg. 1996;54(10):1161–9.
- 41. Lippold C, Kruse-Losler B, Danesh G. Treatment of
hemimandibular hyperplasia: The biological basis of
condylectomy. Br J Oral Maxillofac Surg. 2007;45(5):353–
60.
- 42. Villanueva-Alcojol L, Monje F, González-García R.
Hyperplasia of the Mandibular Condyle: Clinical,
Histopathologic, and Treatment Considerations in a Series
of 36 Patients. J Oral Maxillofac Surg. 2011;69(2):447–55.
- 43. Yamashita Y, Nakamura Y, Shimada T. Asymmetry of the
lips of orthognathic surgery patients. Am J Orthod Dentofac
Orthop. 2009;136(4):559–63.
- 44. Gc R, Muralidoss H, Ramaiah S. Conservative management
of unilateral condylar hyperplasia. Oral Maxillofac Surg.
2012;16:201-5.
- 45. Xavier SP, de Santana Santos T, Silva ER. Two-Stage
Treatment of Facial Asymmetry Caused by Unilateral
Condylar Hyperplasia. Braz Dent J. 2014;25(3):257–60.
- 46. Marchetti C, Cocchi R, Gentile L. Hemimandibular
hyperplasia: treatment strategies. J Craniofac Surg.
2000;11(1):46–53.
- 47. Deleurant Y, Zimmermann A,Peltomäki T. Hemimandibular
elongation: treatment and long-term follow-up.
Orthodontics & Craniofacial Research.2008;11(3):172-9.
- 48. Matteson SR, Proffit WR, Terry BC. Bone scanning
with99mtechnetium phosphate to assess condylar
hyperplasia: Report of two cases. Oral Surgery, Oral Med
Oral Pathol. 1985;60(4):356–67.
- 49. Sugawara Y, Hirabayashi S-I, Susami T. The Treatment
of Hemimandibular Hyperplasia Preserving Enlarged
Condylar Head. Cleft Palate-Craniofacial J. 2002;39(6):646–
54.
- 50. Olate S, Netto HD, Rodriguez-Chessa J. Mandible condylar
hyperplasia: a review of diagnosis and treatment protocol.
Int J Clin Exp Med. 2013.
- 51. Cervelli V, Bottini DJ, Arpino A. Hypercondylia: Problems
in diagnosis and therapeutic indications. J Craniofac Surg.
2008;19(2):406–10.