Effect of Psyllium Husk Based Dietetic Cookies on Hematologial Parameters of Normal and Hypercholesterolemic Subjects

Effect of Psyllium Husk Based Dietetic Cookies on Hematologial Parameters of Normal and Hypercholesterolemic Subjects

Dietary fiber plays key role in the normal physiology of human. Psyllium husk is gaining attention as functional diet ingredient against hypercholesterolemia and its allied discrepancies. Cookies prepared with psyllium husk supplementation were administered to normal and hypercholesterolemic patients in Trial-I and II. The objective was to efficacy and safety of psyllium husk as diet supplement in the human subjects. Results for hematological tests depicted safe range in allied parameters i.e. platelets count, ESR, red blood cells and white blood cells indices. It is interesting to mention that the ESR of hypercholestrolemic subjects was momentously affected by using therapeutic diet (T4) as it was reduced to 5.61 and 6.98% in Trial-I & II, respectively. From the current explorations it is concluded that psyllium husk based cookies (supplemented with 20% psyllium husk) have potential to be used as a functional ingredient against the menace of hypercholestolemia. 

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  • References1. Al-Haj M., Kazzam E., Nagelkerke N.J., Nyberg F., Nicholls M.G., Adem A. 2011. Effect of dehydration in the presence and absence of the angiotensin receptor blocker losartan on blood constituents in the camel. J. Med. Sci. V.4, p73-78.2. Bonaccio M., Castelnuovo A.D., De Curtis A., Costanzo S., Persichillo M., Donati M.B., Cerletti C., Iacoviello L., de Gaetano G. 2014. Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study. Blood. V.123, p3037-3044. 3. Carabin L.G., Lyon M.R., Wood S., Pelletier X., Donazzolo Y., Burdock G.A. 2009. Supplementation of the diet with the functional fiber PolyGlycoplex® is well tolerated by healthy subjects in a clinical trial. Nutr. J. V.8, p68-77.4. Choi J.W., Pai S.H.W. 2004.Influences of hypercholesterolemia on red cell indices and erythrocyte sedimentation rate in elderly persons. Clinica. Chimica. Acta.V.341, p117-121.5. CoStat Statistical Software, 2003. CoHort v. 6.2, Monterey, CA.6. Gijsen F.J., Wentzel J.J., Thury A., Mastik F., Schaar J.A., Schuurbiers J.C., Slager C.J., van der Giessen W.J., de Feyter P.J., van der Steen A.F., Serruys P.W. 2008. Strain distribution over plaques in human coronary arteries relates to shear stress. Am. J. Physiol. Heart. Circ. Physiol. V.295, p1608 –1614.7. Granger D.N. 1999. Ischemia-reperfusion: mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation, V.6, p167–178.8. Jenkins D.J.A., Kendall C.W.C., Nguyen T.H., Teitel J., Marchie A., Chiu M., Taha A.Y., Faulkner D.A., Kemp T., Wong J.M.W., de Souza R., Emam A., Trautwein E.A., Lapsley K.G., Holmes C., Josse R.G., Leiter L.A., Singer W. 2007. Effect on the hematologic risk factors for coronary heart disease of a cholesterol reducing diet. Eur. J. Clin. Nutr. V.61, p483-492.9. King D.E., Mainous A.G., Egan B.M., Woolson R.F., Geesey M.E. 2008. Effect of psyllium fiber supplementation on C-reactive protein: the trial to reduce inflammatory markers (TRIM). Ann. Fam. Med. V.6, p100-106.10. Liu M., Reilly M.P., Casasanto P., McKenzie S.E., Williums K.J. 2007. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles. Arterioscler. Thromb. Vasc. Biol. V.27, p430-435.11. Prasad K. 2005. Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system. Mole. Cell. Biochem. V.270, p139-145.12. Ross R. 1999. Atherosclerosis: an inflammatory disease. N. Engl. J. Med. V.340, p115–126.13. Steel R.G.D., Torrie J.H., Dickey D. 1997. Principles and Procedures of Statistics: A biometrical approach. 3rd Ed. McGraw Hill Book Co. Inc., New York, USA.14. Stokes K.Y., Cooper D., Tailor A., Granger D.N. 2002. Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide. Free Radic. Biol. Med. V.33, p1026–1036.15. Tailor A., Granger D.N. 2004. Hypercholesterolemia promotes leukocyte-dependent platelet adhesion in murine postcapillary venules. Microcirculation. V.11, p597-603.16. Thompson A.R., Harker L.A. 1983. Manual of Hemostasis and Thrombosis. 3rd Ed. F.A. Davis, Philadelphia, USA.17. Widmann F.K. 1983. Clinical Interpretation of Laboratory Tests. 9th Ed. F.A. Devis, Philadelphia, USA.