Zeki ALKAN, Ali BUMİN, Yaşar ŞEKER, Tolga GÜVENÇ

Tavşanlarda İntraabdominal Adezyonların Önlenmesinde Heparin, Streptokinaz, Vitamin-E ve Selenyum Kullanılması Üzerine Deneysel Çalışmalar

Adezyonlar, periton yüzeyleri arasında oluşan anormal birleşmelerdir. Operasyon sonrası perİtonal yapışmalar, ciddi bir cerrahi problem olarak ortaya çıkar. Sınırlı başanya sahip değişik metotlar, perİtonal adezyonlann oluşumunu azaltmak için denenmiştir.Bu metotlar, postoperatif olarak şekillenen fibrinöz eksudatın proteolitik enzimlerle lavajı, steroidler, antihistaminikler ve sitotoksik ajanlar kullanılarak fibroblastik aktivasyonun inhibisyonu ve perİtonal yüzeylerin mekanik olarak ayrılması şeklinde sınıflandınlmıştır. Bu çalışmada, heparin'in 40 ünite/kg ve streptokinaz'ın 90.000 İU/kg intraperitonal olarak ı2 saat ara ile 4 kez, vitaminE'nin 300 mg/kg ve Sodyum selenit'in 0.5 mg/kg olarak operasyondan 24 saat önce, operasyon sonrası ve 24 saat sonra olmak üzere kas içi uygulanması ile kontrol grubuna oranla başarılı sonuçlar alınmıştır.

Anahtar Kelimeler:

Tavşan, İntraabdominal Adezyonlar, Heparin, Streptokinaz, Vitamin-E, Selenyum, Zeki ALKAN, Ali BUMİN, Yaşar ŞEKER, Tolga GÜVENÇ

The experimental study on heparin, streptokinase, Vitamin-e and selenium for the prevention Of intraabdominal adhesions in rabbits

Adhesions are abdominal connections between peritoneal surfaces. Postoperative peritoneal adhesions continue to be a serious surgical problem various methods have been tried with lirriited success to reduce the ineidence of peritoneal adhesions. These methods as the prevention of fibrin depositian in the postoperative period, the removal of the fibrinous exudate, which follows any surgical procedure by peritoneal surfaces and the inhibition of fibroblast proliferation using cytotoxic agents, antihistamines and steroids. In this study, 40 unit/kg heparİn or 90.000 IU/kg streptokinase were applied intraabdominally 4 times with 12 hours intervals, vitamin-E 300 mg/kg or sodium selenit 0.5 mg/ kg IM 24 hours preoperativeiy, peroperatively and 24 hours postoperatively. All these methods found to be meaninigful better than control gruoups.

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