İki Maymunda Görülen Tüberküloz Olgusu

Farklı iki ilimizin hayvanat bahçelerinden U. Ü. Veteriner Fakültesi Patoloji Anabilim Dalı 'na (Olgu ı) ve Bursa il Kontrol Laboratuvar Müdür! üğü ' ne (O lg u 2) nekropsi için getirilen iki Eski Dünya maymunundaki tüberküloz olgusu incelenmiştir. Bir maymundan (Olgu I) Mycobacterium spp. İzolasyonu yapılmış ancak, identifıkasyon gerçekleştirilememiştir. Makroskobik olarak her iki maymunun akcigerinde subplöyral ve parankimatöz, boz-beyaz renkli, milier, dissemine nodüller görülmüş , bronşiyal lenf nodüllerinde de tüberküller saptannuştır. Sadece, birinci olgumm karaciğerinde tüberküloz lezyonlan görülmüş ,dalak ve böbreklerdeki Iezyonlara ise her iki olguda da rastlanmıştır.Barsak,mezenteriyel lenf yumruları, beyin, kemik ve deride her iki maymuncia da lezyongörülemeıniştir. Tüberküller tek veya konglomere olup, nekroz, epiteloid hücreler,Langhans tipi dev hücreleri ve bağ doku kuşağındanoluşmuştur. Kazeifıkasyonayalnızca 1. olgunun dalagında rastlanmıştır. Birinci olgunun sol gözünün koroid ve retina tabakalarında göriilen epiteloid histiyosit ve az sayıdaki dev hücre infiltrasyonları tipik tüberkül yapısında olmadığından ve Ziehl-Neelsen tekniği ile yapılan boyama negatif sonuç verdiğinden tüberküloz lezyonu olarak değerlendirilmemiştir. Ziehl-Neelsen tekniği ile yapılan boyaınada, her iki olguda akciğerlerde yoğun olmak üzere, böbrek ve dalaktaki tüberküllerde çomak şeklinde, aside-dirençli mikroorganizma! ara rastlanmıştır.

Anahtar Kelimeler:

Maymun, Tüberküloz, M. Müfit KAHRAMAN, Figen KAHRAMAN, 1996, Etlik Veterinerlik Mikrobiyoloji Dergisi, Mycobacterium spp.

Tüberculosis Cases In Two Monkeys

Tuberculosis casesin two Old Wold monkeys, from the zoos oftwo different cities in Turkey, submitted for necropsy to the Department of Pathology Veterinary. Faculty, Uludag University (Case 1) and Bursa, City Control Laboratory (Case 2) were exarnined. White in one ofthe monkeys (Case 1) Mycobacterium tuberculosis was isolated and identifıed, in the other (Case 2) isolation of the Mycobacterium s pp. was made, yet identifıcation was not accomplished. Macroscopically, in both cases, subpleural and parenchymatous grey to white, miliary, disseminated nodules in the lungs \vere observed. Bronchial lymph nodes contained similar nodules. Tuberculotic lesions of the li ver were observed in Case 1 only, yet spleen and kidneys had been affected in both cases. Neither in Case I nor in case two, no tuberculotic lesions were seen in the intertines, mesenteric lymph nodes, cerebrum, bones, and the skin. Tubercles were either in s ing! e or conglomerated appearance microscopically, and generally composed of necrosis, epithelioid cells, Langhans type giant cells, and surraunding connective tissue. Caseation of the tubercles were only observed in the spleen. In the choroid and retina ofthe left eye of the case 1, cell infıltrations with epithelioid cells and few giant cells were not evaluated as tuberculotic lesions since they were not in the fonn of tu bere! e and also did not contain acid-tast bacteria in Ziehl-Neelsen stain. In both cases, with Ziehl-Neelsen stain, acid-fast bacteria being more abundant in the lungs, kidneys and spleen \.vere observed.

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