In Vitro Cytotoxic Evaluation of a Silver(I) Complex Including Non-Steroidal Anti-Inflammatory Drug Niflumic Acid and 3-Picoline on Human-Derived Cancer Cell Lines

In Vitro Cytotoxic Evaluation of a Silver(I) Complex Including Non-Steroidal Anti-Inflammatory Drug Niflumic Acid and 3-Picoline on Human-Derived Cancer Cell Lines

Burada, steroidal olmayan anti-enflamatuar ilaç niflumik asit ve 3-pikolin içeren yeni bir gümüş(I) kompleksi sentezlendi ve FT-IR, 1H NMR, elemental ve termik analiz teknikleri ile karakterize edildi. Bu teknikler, sentezlenen kompleksin formülünün [Ag(nif)(3-pic)] olduğunu gösterdi. Kompleks, ligand (niflumik asit) ve gümüş iyonlarının tek başına sitotoksik yeteneği, insan meme adenokarsinomu (MDA-MB-453), akciğer adenokarsinomu (A-549), kolorektal adenokarsinom (HT-29) ve fare fibroblast hücre hatlarına (3T3-L1) karşı test edildi. XTT sonuçları, AgNO3 ve niflumik asidin tek başına kanser ve sağlıklı hücre hatları üzerinde orta düzeyde sitotoksisite sergilemesine rağmen, kompleksin kanser hücreleri üzerinde doza bağlı bir şekilde güçlü sitotoksik aktivite gösterdiğini gösterdi. Kompleksin en güçlü sitotoksisitesi ve en yüksek seçiciliği HT-29 hücrelerinde belirlendi. Bu bulgular, gelişmiş antikanser çalışmalarında yeni gümüş(I) kompleksinin değerlendirilmesi için temel çıktılar sağlar.

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Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi-Cover
  • ISSN: 1307-9085
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2008
  • Yayıncı: Erzincan Binali Yıldırım Üniversitesi, Fen Bilimleri Enstitüsü
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