Nükleer Reseptörler

Gen ifadesinin kontrolü, modern moleküler biyolojinin merkezi ve önemli bir amacı haline gelmiştir. Nükleer resep- törler, tipik olarak hedef genler ile birlikte DNA yanıt elementlerine bağlanarak genetik ifadeyi düzenler. Son yıllarda yapılan araştırmalar, nükleer reseptör ailesinin, vücudun içindeki birçok kimyasal düzeyindeki dalgalanmalara karşı vücudun tepkisine esas faktör olduğunu ortaya koymuştur. Nükleer reseptörler metabolizma, homeostaz, farklılaşma, büyüme ve gelişme, yaşlanma ve üretim (hücre yenilenmesi) gibi birçok fizyolojik süreçte önemli roller oynar. Nükleer reseptör fonksiyonları çok karmaşıktır ve birbiri ile bağlantılıdır. Bu karmaşıklığa rağmen nükleer reseptör ailesi önemli ilaç hedefleri olarak yer almaktadır. Bu derlemede insan ve hayvanlarda bulunan nükleer reseptör ailesi ve fonksiyonla- rı hakkında bilgiler verildi.

Anahtar Kelimeler:

Genetik ifade, hücre yenilenmesi, ilaç hedefleri, nükleer reseptörler, steroid reseptör

Nuclear Receptors

Control of gene expression has become a central theme in modern molecular biology. nuclear receptors typically regulate gene expression through binding to DNA response elements associated with target genes. Research over the past decade has demonstrated that the nuclear receptor family is intrinsic to the body’s response to fluctuations in the levels of many chemicals within the body. Nuclear receptors play an important role in many physiological processes such as metabolism, homeostasis, differentiation, growth and development, aging, and reproduction. Functions of nuclear receptors are highly complex and connected with each other. Despite this complexity, the nuclear receptor family has had a long history of successful drug discovery. With this review, it was given about nuclear receptor family and its functions in human and animals.

Keywords:

Cell expression, drug targets, genetic expression, nuclear receptors, steroid receptor,

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