Tarık MECİT, Nadide NABIL KAMILOĞLU, Pelin ŞAHIN, Dinçer ERDAĞ, Oğuz MERHAN

Hipertansiyonda L-karnitin ve Ko-enzim Q10'un Oksidatif Stres Hasarına Karşı Koruyucu Etkileri

Bu çalışmada, L-NAME hipertansif sıçanlarda ACE İnhibitörü (ACE inh.) ile birlikte L-carnitine ve Co-enzyme Q10 uygulamasının karaciğer, beyin ve böbrek dokularında oksidatif stres parametreleri üzerine etkilerinin araştırılması amaçlanmıştır. Çalışmada,14 günlük deney süresine sahip dört grup ve 28 günlük deney süresi sahip olan dört grup olmak üzere sekiz gruba ayrıldı. Deney sonunda sıçanlara ötenazi uygulanarak karaciğer, beyin ve böbrek dokuları alındı. Doku süpernatanlarında malondialdehit (MDA), glutatyon (GSH) ve nitrik oksit (NO) aktiviteleri ölçüldü. Tüm dokularda NO ve MDA seviyeleri yükselirken, GSH seviyelerinde belirgin bir düşüş gözlendi (P<0.001). Sonuç olarak L- karnitin ve CoQ10 takviyesinin, daha yüksek düzeyde oksidatif stres ve inflamasyona eğilimli hastalar için bir kom- binasyon tedavisi stratejisi olarak düşünülebileceği önerilmektedir.

Anahtar Kelimeler:

ACE inhibitörü, hipertansif, koenzim Q10, L-karnitin

Protective Effects of L-carnitine and Co-enzyme Q10 Against Oxidative Stress Damage in Hypertension

In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P<0.001). In conclusion, it is suggested that supplementation of L-carnitine and CoQ10 can be considered as a combination therapy strategy for patients prone to higher levels of oxidative stress and inflammation.

Keywords:

ACE inhibitor, Co-enzyme Q10, hypertensive, L-carnitine,

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