Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması

Boynuz köreltme sığırlar için stresli/ağrılı tepki eşliğinde fizyolojik, davranışsal ve nöroendokrin değişikliklere neden olur. Non-steroid anti-inflamatuar ilaçlar boynuz ile bağlantılı ağrı tepkisini azaltır; Ancak, hemostaz üzerindeki etkinlikleri iyi bilinmemektedir. Ayrıca, sığır hemostatik profili pıhtılaşma değişiklikleri veya işlev bozukluğunu önlemek amacıyla ameliyat öncesi göz önüne alınmalıdır. Bu çalışmada, boynuzsuzlaştırma yapılan Holstein düvelerde meloksi-kam ve fluniksin meglumin uygulamasının pıhtılaşma profillerine etkinliğini değerlendirmek amacıyla yapılmıştır. Düve-lere (n=14) boynuzsuzlaştırma öncesi meloksikam (0.5 mg/kg, i.v.) veya fluniksin meglumin (2.2 mg/kg, i.v.) tek doz halinde uygulandı. Fibrinojen (F), protrombin zamanı (PT) ve aktive edilmiş kısmi tromboplastin zamanı (APTT) boy-nuzsuzlaştırmadan önce (0. dakika) ve boynuzsuzlaştırma sonrası 90 dakika olarak belirlendi. Meloksikam uygulanan düvelerde fibrinojen konsantrasyonu (ortalama ± SEM) başlangıç değerlerinin (212.86±8.13 mg/dl) aksine 90 dakika sonra (238.83±14,22 mg/dL) anlamlı artış gösterdi (P<0.05). Diğer pıhtılaşma parametrelerinde önemli bir değişiklik tespit edilmedi. Boynuz kesimi uygulanan düvelerde meloksikam ve fluniksin meglumin’in tek doz intravenöz uygulama-larının seçilen hemostatik değişkenlerde önemli değişikliklere neden olmadığı gözlendi.

Anahtar Kelimeler:

Boynuzsuzlaştırma, flunixin meglumine, hemostatik fonksiyon, meloxicam, sığır

Comparison of the Efficacies of Meloxicam and Flunixin Meglumine on some Haemostatic Variables in Dehorned Holstein Heifers

Dehorning may cause physiologic, behavioral and neuroendocrine alterations accompanied by a stressful/painful response among cattle. Non-steroidal anti-inflammatory drugs mitigate the pain response related to dehorning; however, their efficacy on hemostasis is not well-known. Moreover, the haemostatic profile of cattle has to be taken into consideration prior to surgery in order to prevent alterations or dysfunction in coagulation. This study was conduct-ed to evaluate the efficacy of meloxicam and flunixin meglumine administration on the coagulation profiles of Holstein heifers subjected to dehorning. Heifers (n=14) were administered either meloxicam (0.5 mg/kg, i.v.) or flunixin meglu-mine (2.2 mg/kg, i.v.) in a single dose prior to dehorning. Fibrinogen (F), prothrombin time (PT), and activated partial thromboplastin time (APTT) were determined prior to dehorning (time 0) and 90 minutes after administration. Fibrino-gen concentration (mean ± SEM) in the heifers that received meloxicam was significantly increased (P<0.05) 90 minutes after administration (238.83±14.22 mg/dL) in contrast to initial values (212.86±8.13 mg/dL). Significant differ-ences were not detected in other coagulation panel parameters at sampling times. Intravenous administration of single dose meloxicam or flunixin meglumine was determined not to cause significant changes of selected haemostatic varia-bles in heifers subjected to dehorning.

Keywords:

Cattle, dehorning, flunixin meglumine, hemostatic function, meloxicam,

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