M. Kazım BÖRKÜ, Murat GÜZEL, M. Çağrı KARAKURUM, Buğrahan B. YAĞCI

Bir köpekte kalsiyum okzalat kristalüri'sinin potasyum sitrat ve vitamin $B_6$ ile sağaltımı

Bu çalışmanın materyalini 7 kg ağırlığında 10 aylık terrier ırkı bir köpek oluşturdu. Anamnezde köpeğin bir haftadır oldukça durgun olduğu ve idrar yaparken zorlandığı öğrenildi. Ultrasonografik muayenede idrar kesesinde bol miktarda, hiperekojen görüntü veren kristal ve idrar kesesi duvarında kalınlaşma tespit edildi. Sistosentez ile alınan idrarın mikrobiyolojik ve biyokimyasal kontrolleri yapıldı. Sistosentezden sonra hasta obstrüksiyon olup olmadığını tespit amacı ile sondalandı. İdrar muayenesinde dansite 1.020, pH 6 bulundu. İdrarın mikroskopİk muayenesinde bol miktarda kalsiyum okzalat kristali, 3-4 kalsiyum okzalat kristali kümesi görüldü. İdrar kültüründe üreme olmadı. Sağaltım amacı ile 200/mg/kg total dozda günde üç kez potasyum sitrat (Kalinor eff. TabletÖ, Knoll), günde iki kez Vitamin B6 25 mg/kg (Benexol tabletö, Roche) oral, günde 2 kez Amoksisilin+klavulanik asit (Synulox enj. Ö, Pfizer) 15 mg/kg İM, günde 1 kez Karprofen (Rimadyl enj. Ö Pfizer) 2 mg/ kg dozda SC uygulandı. Sağaltımdan 14 gün sonra yapılan kontrollerde idrarda kalsiyum okzalat kristallerinin kaybolduğu belirlendi. Bu çalışma ile köpeklerde görülen kalsiyum okzalat kristalürinin uygulanan bu yöntemle sağaltılabilirliğinin gösterilmesi amaçlanmıştır.

Treatment of calcium oxalate cristalluria with potassium citrate and vitamine $B_6$ in a dog

The material of this study is a 10-month-old, 7 kg weight terrier dog, which was referred to A.U, School of Veterinary Medicine Department of Internal Medicine. According to anamnesis and laboratory findings calcium oxalate crystalluria was diagnosed. Urinary bladder was found full-filled in the abdominal palpation. In ultrasonographic examination a great deal of crystals that give hyperechogen view in the urinary bladder was confirmed. After the cystocentesis the patient was catheterized to determine a possible presence of obstruction. Blood sample was collected and CBC and serum biochemistry analyses were performed. Urinalysis revealed specific gravity of 1.020 and pH as 6, and large numbers calcium oxalate crystals and 3-4 calcium oxalate casts per microscopic field. Bacteriological culture of the urine yielded no growth. In the treatment potassium citrate (Kalinor eff. tablet, Knoll) in a total dose of 200/mg/kg, three times a day, Vitamin B6 (Benexol tablet) in a dose of 25/mg/kg twice a day, Amoxicillin+Klanulanic acid (Synulox enj. Ö, Pfizer) in a dose of 15 mg/kg twice IM, Carprofen (Rimadyl inj. Pfizer) in a dose of 2mg/kg IM were given. 14 days after the treatment it was determined that calcium oxalate crystals had disappeared in the urine. In this study, it was aimed to show that calcium oxalate that is frequently seen among dogs could be treated by this method.

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