H Bengü ÇOBANOĞLU, SELÇUK ARSLAN, Ümit ÇOBANOĞLU, Mehmet İMAMOĞLU

Reinke ödeminde enflamatuvar hücre tipleri

Reinke ödeminde enflamatuvar hücre tipleri Amaç: Reinke ödemindeki histopatolojik bulguları değerlendirmekve disfoni dışındaki otorinolarengolojik semptomlarla ilişkilendirmek. Yöntem:Bu retrospektif çalışmaya, disfoninin kaynağı olarakOcak-Aralık 2016 arasında Reinke ödemi tanısı konan hastalar dahiledildi. Reinke ödeminde histopatolojik bulguların disfoni dışındakiotolarengolojik semptomlarla korelasyonu değerlendirildi. Bulgular:Tümü sigara kullanan 3'ü kadın ve 10'u erkek, toplam 13Reinke ödemli hasta ameliyat edilmişti. Tüm örneklerde esas histopatolojik bulgu ses tellerinin lamina propriasındaki ödem idi. Subepitelyal zonun tümüyle mikroskobik değerlendirmesiyle stromadaki başatenflamatuvar hücre tipi belirlendi. Hücre tipleri plazma hücreleri,lenfositler, monositler ve nötrofillerden ibaretti. Sonuç:Reinke ödeminde asıl patolojik bulgu Reinke mesafesindeödemli sıvı koleksiyonudur. Çalışmamız az sayıda olgu ile sınırlanmışolduğundan, enflamatuvar hücre tipleriyle Reinke ödeminin kliniközellikleri arasında istatistiksel açıdan anlamlı bir korelasyon saptayamadık.

Inflammatory cell types in Reinke's edema

Objective:To evaluate the histopathological findings in Reinke'sedema and correlate them with otorhinolaryngologic symptoms otherthan dysphonia. Methods:Patients diagnosed with Reinke's edema as the source of dysphonia from January to December 2016 were included in this retrospective study. The histopathological findings in Reinke's edema andthe correlation with otorhinolaryngologic symptoms other than dysphonia were evaluated. Results: A total of 13 patients (3 females, 10 males) with Reinke's edemaall of whom were smokers underwent surgery. In all of the specimens, themain histopathological finding was edema in the lamina propria of thevocal folds. The dominant inflammatory cell type in the stroma was determined by evaluating the whole microscopic subepithelial zone. The celltypes included plasma cells, lymphocytes, monocytes, and neutrophils. Conclusion:In Reinke's edema the main pathologic finding is the collection of edematous fluid in Reinke's space. As our study was limitedby the small number of cases, we could not find any statistically significant correlation between the inflammatory cell types and clinical characteristics of Reinke's edema.

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