Laringofaringeal reflü

Gastroözefajial reflü hastalığı, Batı dünyasındaki yetişkin nüfusun yaklaşık %35-40 kadarını etkileyen bir rahatsızlıktır. Laringofaringeal reflü ise, bunun larinks ve farinksi etkileyen, özefagus dışı bir türevidir. Son yıllarda birçok otorinolaringolojist, yakınması olan hastalarda laringofaringeal reflünün hadiseye katkısını saptayıp tanımladılar. Laringofaringeal reflünün kesin sıklığı bilinmemekle birlikte; kulak burun boğaz polikliniklerine başvuran hastaların %10'unda altta yatan nedenin bu olduğu düşünülmektedir. Bu çalışmada, laringofaringeal reflünün ana hatlarını tanımlamaya ve günümüzdeki tanı ve tedavi seçeneklerini özetlemeye çalıştık.

Laryngopharyngeal reflux

Gastroesophageal reflux disease is a common medical condition affecting approximately 35%-40% of the adult population in the Western world. Laryngopharyngeal reflux is an extraesophageal variant of gastroesophageal reflux disease that affects the larynx and pharynx. In recent years, many otolaryngologists have acknowledged the existence and potential importance of laryngopharyngeal reflux in patients with otolaryngologic complaints. The exact prevalance of laryngopharyngeal reflux is unknown. However, there is increasing evidence that gastroesophageal reflux disease may cause rhinological and laryngopharyngeal symptoms and at least 10% of all patients presenting to the otolaryngologists, have symptoms related to gastroesophageal reflux disease. Here we tried to summarize the mainlines of the larynopharyngeal reflux disease and diagnosis-treatment options up to date.

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  • Spechler SJ. Epidemiology and natural history of gastro- oesophageal reflux disease. Digestion 1992;51 Suppl 1:24-9.
  • Vaezi MF. Therapy insight: gastroesophageal reflux disease and laryngopharyngeal reflux. Nat Clin Pract Gastroenterol Hepatol 2005;2:595-603.
  • Vakil N, Van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900-20.
  • Sataloff RT, Castell DO, Katz PO, Sataloff DM. Reflux laryngitis and related disorders, 3rd ed. San Diego: Plural Publishing, Inc.; 2006.
  • Tauber S, Gross M, Issing WJ. Association of laryngopharyngeal symptoms with gastroesophageal reflux disease. Laryngoscope 2002;112:879-86.
  • Gursky RR, Da Rosa ARP, Do Valle E, de Borba MA, Valiati AA. Extraesophageal manifestations of gastroesophageal reflux disease. J Bras Pneumol 2006;32:150-60.
  • Poelmans J, Feenstra L, Demedts I, Rutgeerts P, Tack J. The yield of upper gastrointestinal endoscopy in patients with suspect- ed reflux-related chronic ear, nose, and throat symptoms. Am J Gastroenterol 2004;99:1419-26.
  • Hogan WJ, Shaker R. Supraesophageal complications of gastroe- sophageal reflux. Dis Mon 2000;46:193-232.
  • Sataloff RT, Hawkshaw MJ, Gupta R. Laryngopharyngeal reflux and voice disorders: an overview on disease mechanisms, treat- ments, and research advances. Discov Med 2010;10:213-24.
  • Ahmad I, Batch AJ. Acid reflux management: ENT perspective. J Laryngol Otol 2004;118:25-30.
  • Richardson BE, Heywood BM, Sims HS, Stoner J, Leopold DA. Laryngopharyngeal reflux: trends in diagnostic interpretation cri- teria. Dysphagia 2004;19:248-55.
  • Toros SZ, Toros AB, Özel L, et al. Investigation of gastric pepsinogen in middle ear fluid of children with glue ear. Acta Oto- Laryngologica 2010;130:1220-4.
  • Karkos PD, Assimakopoulos D, Issing WJ. Pediatric middle ear infections and gastroesophageal reflux. Int J Pediatr Otorhino- laryngol 2004;68:1489-92.
  • Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux dis- ease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol 1989;84:1503-8.
  • Harrell SP, Koopman J, Woosley S, Wo JM. Exclusion of pH arti- facts is essential for hypopharyngeal pH monitoring. Laryngoscope 2007;117:470-4.
  • Joniau S, Bradshaw A, Esterman A, Carney AS. Reflux and laryn- gitis: a systematic review. Otolaryngol Head Neck Surg 2007;136: 686-92.
  • Postma GN, Belafsky PC, Aviv JE, Koufman JA. Laryngopha- ryngeal reflux testing. Ear Nose Throat J 2002;81:14-18.
  • Vaezi MF. Sensitivity and specificity of reflux-attributed laryngeal lesions: experimental and clinical evidence. Am J Med 2003;115 Suppl 3A:97S-104S.
  • Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001;111:1313-7.
  • Hopkins C, Yousaf U, Pedersen M. Acid reflux treatment for hoarseness. Cochrane Database Syst Rev 2006;(1):CD005054.
  • Farrokhi F, Vaezi MF. Extra-esophageal manifestations of gastroe- sophageal reflux. Oral Dis 2007;13:349-59.
  • Lowe RC, Wolfe MM. Esophageal disorders. In: Andreoli TE, Carpenter CJC, Griggs CR, Benjamin JI, editors. Andreoli and Carpenter's Cecil essentials of medicine. 7th ed. Philadelphia: Elsevier Saunders; 2007. p. 384-9.
  • Sataloff RT, Castell DO, Katz PO, Sataloff DM. Surgical therapy for gastroesophageal reflux disease. In: Reflux laryngitis and relat- ed disorders. 3rd ed. San Diego: Plural Publishing, Inc.; 2006. p. 135-62.
  • Bough ID Jr, Sataloff RT, Castell DO, Hills JR, Gideon RM, Spiegel JR. Gastroesophageal reflux disease resistant to Omeprazole therapy. J Voice 1995;9:205-11.
  • Reichel O, Issing WJ. Impact of different pH thresholds for 24- hour dual probe pH monitoring in patients with suspected laryn- gopharyngeal reflux. J Laryngol Otol 2008;122:485-9.
  • Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effec- tive in patients with gastroesophageal reflux disease? An evidence- based approach. Arch Intern Med 2006;166:965-71.
  • Belafsky PC, Postma GN, Koufman JA. Laryngopharyngeal reflux symptoms improve before changes in physical findings. Laryngoscope 2001;111:979-81.
  • Jin BJ, Lee YS, Jeong SW, Joeng JH, Lee SH, Tae K. Change of acoustic parameters before and after treatment in laryngopharyn- geal reflux patients. Laryngoscope 2008;118:938-41.
  • This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
  • NC-ND0) Licence (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted noncommercial use, distribution, and reproduc
  • tion in any medium, provided the original work is properly cited.
  • Please cite this article as: Toros AB, Zer Toros S. Laryngopharyngeal reflux. J Med Updates 2013;3(3):150-153.
ENT Updates-Cover
  • ISSN: 2149-7109
  • Başlangıç: 2015
  • Yayıncı: Prof.Dr.Murat Demir
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