Serkan YALAKİ, Mehmet Suat YALÇIN, Hüseyin PULAT, Aysu İLHAN

Ülseratif kolit hastalarında nötrofil lenfosit oranı ve platelet lenfosit oranı, klinik ve endoskopik aktivite indeksleri ile ilişkili mi?

Amaç: Ülseratif kolitin (ÜK) hastalık aktivitesine ve ciddiyetine göre sınıflandırılması klinik uygulamada önemlidir, çünkü hastanın yönetimini belirler. Bu çalışmada, nötrofil lenfosit oranları (NLR) ve platelet lenfosit oranlarının (PLR), ÜK hastalarında klinik aktivite indeksinin (KAİ) yanı sıra mukozal hastalığa göre hastalık şiddetini belirleyen endoskopik aktivite indeksleri (EAİ) ile olan ilişkilerinin ortaya konulması amaçlanmıştır.Materyal ve Metot: Çalışma retrospektif tek merkezli çalışma olarak planlandı. Yeni tanı almış 99 ÜK’li hastadan KAİ’lerine ve EAİ’lerine göre aktif hastalık ve remisyon grupları oluşturuldu. Kontrol grubu 56 sağlıklı bireyden oluşturuldu.Bulgular: Klinik aktif hastaların serum NLR’ı ve PLR’ı, inaktif ÜK ve kontrol grubuna göre anlamlı derecede yüksekti (p<0,01). NLR ve PLR için kesme değerleri sırasıyla 2,10 (%90 sensitivite, %45 spesifite) ve 152,13 (%70 sensitivite, %33 spesifite) olarak saptandı. Endoskopik aktif hastaların serum NLR’ı ve PLR’ı, inaktif ÜK ve kontrol grubuna göre anlamlı derecede yüksekti (p<0,01). NLR ve PLR için kesme değerleri sırasıyla 2,09 (%97 sensitivite, %39 spesifite) ve 151,72 (%73 sensitivite, %31 spesifite) olarak saptandı. Sonuç: Çalışmamız aktif ÜK hastalarında NLR ve PLR seviyelerinin anlamlı şekilde arttığını ve bunun klinik, endoskopik ve laboratuvar endeksleri ile korele olduğunu göstermiştir. Bu inflamatuar belirteçler tek başına ya da birlikte hastalık aktivitesini tahmin edebilir.

Anahtar Kelimeler:

Ülseratif kolit, Nötrofil lenfosit oranı, Platelet lenfosit oranı, Endoskopik aktivite indeksi, Klinik aktivite indeksi

Do neutrophil-lymphocyte ratio and platelet-lymphocyte ratio correlate with clinical and endoscopic activity indices in ulcerative colitis patients?

Objective: Classification of ulcerative colitis (UC) according to disease activity and severity is important in clinical practice because it determines the management of the patient. In this study, we aimed to investigate the relationship between neutrophil lymphocyte ratios (NLR) and platelet lymphocyte ratios (PLR) with clinical activity index (CAI) in UC patients as well as endoscopic activity indexes (EIA) that determine disease severity relative to mucosal disease.Materials and Methods: The study was planned as a retrospective single-center study. Active disease and remission groups were formed from 99 newly diagnosed UC patients according to their CAIs and EAIs. The control group consisted of 56 healthy subjects.Results: Serum NLR and PLR levels of clinically active patients were significantly higher than inactive UC and control groups (p <0.01). The cut-off values for NLR and PLR were 2.10 (90% sensitivity, 45% specificity) and 152.13 (70% sensitivity, 33% specificity), respectively. Serum NLR and PLR of endoscopically active patients were significantly higher than inactive UC and control group (p <0.01). The cut-off values for NLR and PLR were 2.09 (97% sensitivity, 39% specificity) and 151.72 (73% sensitivity, 31% specificity), respectively. Conclusion: Our study showed that NLR and PLR levels were significantly increased in active UC patients and correlated with clinical, endoscopic and laboratory indices. These inflammatory markers can predict disease activity alone or in combination.

Keywords:

Ulcerative colitis, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio, Endoscopic activity index, Clinical activity index,

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