Şemsettin OSMANOĞLU, Farhad Hamadameen HAMADAMEEN, Ali YEŞİL, Kerem SÜTÇÜ, Yunus Emre OSMANOĞLU

Radyasyonun Lamotrijin ve Flurbiprofen Üzerine Etkisinin EPR Çalışması

Bu çalışmada gama radyasyonun Lamotrijin ve Flurbiprofen’de oluşturduğu hasarları belirlemek için Elektron Paramanyetik Rezonans Spektroskopisi kullanıldı. Örneklerde oluşan serbest radikallerin bazı alkil ve amin türü radikaller olabileceği şeklinde yorumlandı. Radikallerin g değerleri ve aşırı ince yapı sabitleri belirlendi. Örneklerin spektrum simülasyonları bilgisayar kullanılarak gerçekleştirildi. Örneklerde oluşan serbest radikallerin oda sıcaklığında iki aydan daha fazla kararlı olduğu ortaya çıktı

Anahtar Kelimeler:

EPR, ilaç, serbest radikal, gama radyasyonu

Radiation Effects on Lamotrigine and Flourbiprofen: an EPR study

Electron paramagnetic resonance (EPR) spectroscopy was used to determine the gamma radiation damages in Lamotrigine and Flurbiprofen.The free radicals produced in the samples were interpreted in terms of some type of alkyl and amine radical fragments. The g values and hyperfine structure constants of the radicals were determined and the spectra were computer simulated. In this study, the free radicals were appeared to be stable at room temperature for more than two months.

Keywords:

EPR, drugs, free radicals, gamma irradiation,

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References
Diehl, J.F., 2002. Food irradiation-past, present and future. Radiat. Phys. Chem. 63, 211-215
Gibella, M., Crucq, A.S.,Tilquin, B., Stocer, P., Lesgards, G., Raffi, J., 2000. Electron spin resonance studies of some irradiated pharmaceuticals. Radiat. Phys. Chem. 58, 69-76
Petrişor, D., Damian, G., Ionila, M., Dragan, F., Simon, S., 2004. EPR study of radical kinetics in some γ-irradiated beta- blocker drugs. Stud. Univ. Babes-Bol. Phys. XLIX. 3, 23-29
Sivri, N.N., Özer, A.Y., Özalp, M., Atakan, N., Polat,M., 2006. Decontamination of cosmetic products and raw materials by gamma irradiation. FABAT J, Pharm. Sci., 31, 198-209
Damian, G., 2003. EPR investigation of gamma-irradiated anti-emetic drugs. Talanta, 60, 923-927
Basly, J.P., Basly, I., Bernard. M., 1998. Radiosterilization dosimetry of vitamins: an ESR study. Int. J. Radiat. Biol. 74, 521-528
Piccerelle, P., Reynier, J.P., Joachim, J., Tilquin, B., J.Raffi, J., 2000. J. Pharma. Belg, 131-136
Jacobs, G.P., 1985. A review: Radiation sterilization of Pharmaceuticals. Radiat. Phys. Chem., 26, 133-142
Crucq, A.S., 1994. Etude de mecanismesradicalaires de medicaments irradies. Chim. Nouvelle, 12, 1356-1359
Yordanov, N.D., Gancheva, V., 2000. A new approach for extension of the identification period of irradiated cellulose containing foodstuffs by EPR spectroscopy. Appl. Rad. Isotopes, 52,195-198
McKelvey, R.D., 1987. J. Chem. Educ., 64, 479
Asadollahi, M., Ramezani, M., Karimialavijeh, E., Tavakolian, M., Ramezani, M., 2015. Can physiologic menstrual cycle change serum lamotrigine concentration?.Seizure, 33, 35-37
Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C., 2015. Pharmacological and neuroethological study of the acute andchronic effects of lamotrigine in the genetic audiogenic seizurehamster (GASH:Sal). Epilepsy and Behavior
Morton, J.R., 1964. Electron spin resonance spectra of oriented radicals. Chem. Rev., 64, 453
Wood, D.E., Loyd, R.G., 1969. Isotropic EPR spectra from free radicals trapped in an adamantine matrix. J. Chem. Phys. 52, 3840
Başkan, M.H., Aydın, M., Osmanoğlu, Ş., 2007. EPR of γ-irradiated single crystal of iminodiacetic acid. Radiat. Eff. Def. in Solid. 163, 65-70
Jang, Y.J., Cho, K.H., 2016. Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method. Asian Journal of pharmaceutical sciences II, 108-109
Zhanga, L., Zhanga, Q., Wanga, X., Zhangb, W., Lina C., Chena, F., Yanga, X., Pana, W., 2015. Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen. Int. J. Pharmaceutics, 492, 40-45