Wheat is one the most important cereal crops of the world. As it major crop commodity for food security, there is a need to increase wheat production by developing new high yielding and climate resilient varieties,to meet the projected demand of increasing population and with changing climate. In the present review we have discussed the prospects of the advanced genomics approaches for development of climate resilient wheat genotypes and role of advanced technologies like High-throughput phenotyping, next generation sequencing, genomics-assisted breeding, and CRISPR/Cas9 genome- editing have been emphasized for management of abiotic stressors in wheat.