Vibrational spectroscopy analysis of the precipitate form after mixing sodium hypochlorite and chlorhexidine: A potential clinical problem

Objective: The molecular structure of the insoluble brown-colored substance is produced through the reaction of mixing the most common irrigation agents in endodontic treatments as sodium hypochlorite and chlorhexidine has not been fully described in the literature yet. The aim was to analyze the precipitate is formed through the reaction of mixing sodium hypochlorite and chlorhexidine by using Fourier-transform infrared (FT-IR) spectroscopy. Methods: FT-IR spectrum of the experimental precipitate was recorded. The vibrational FT-IR spectrum of the experimental precipitate was analyzed and compared with the spectrum of the chlorhexidine obtained from available databases in transmission mode (4000-400 cm-1). Results: Eight-shift was recorded at 3335, 2436, 2160, 2004, 1896, 1636, 579 and 555 cm-1 in the spectrum. The experimental precipitate was analyzed and the results were compared with the vibrations of chlorhexidine. Conclusion: After interaction with sodium hypochlorite, chlorhexidine structure was broken and was converted to a new insoluble product as 1,6 Hexandiylbis{imino[({[(4-chlorphenyl)ammonio](imino)methyl}amino)methylyliden]}) diammonium.

Sodyum hipoklorit ve klorheksidin karışımından sonra oluşan çökeltinin titreşim spektroskopisi ile analizi: Potansiyel bir klinik problem

Amaç Endodontik işlemlerde en yaygın yıkama ajanları olan sodyum hipoklorit ve klorheksidin ile karıştırılması reaksiyonuyla oluşan çözünmeyen kahverengi renkli maddenin moleküler yapısı henüz literatürde tam olarak açıklanmamıştır. Amaç sodyum hipoklorit ve klorheksidin karıştırma yoluyla oluşan çökeltiyi Fourier-transform infrared (FT-IR) spektroskopisi kullanarak analiz etmektir. Yöntem Deneysel çökeltinin FT-IR spektrumu kaydedildi. Deneysel çökeltinin titreşimli FT-IR spektrumu analiz edildi ve mevcut veri tabanlarından elde edilen iletim modundaki klorheksidin spektrumu ile karşılaştırıldı (4000-400 cm-1). Bulgular Deneysel çökelti spektrumda 3335, 2436, 2160, 2004, 1896, 1636, 579 ve 555 cm-1’de olmak üzere 8 pik kaydedildi. Bu pikler, klorheksidinin titreşimleriyle karşılaştırıldı. Sonuç Sodyum hipoklorit ile etkileşimin ardından, klorheksidin yapısı kırılmış ve yeni bir çözünmeyen ürüne (1,6- Hekzandilbis{imino [({[(4-klorfenil)amonyo](imino)metil} amino) metiliden]})diamonyum)’a dönüşmüştür.

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Ege Üniversitesi Diş Hekimliği Fakültesi-Cover
  • ISSN: 1302-7476
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1979
  • Yayıncı: Ege Üniversitesi
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