FUNDA YILMAZ BARBET, Gül YÜCE, Necmettin ÖZDEMİR, Galip ERSÖZ, Ulus S. AKARCA, Yücel BATUR

Kronik C hepatitinde histopatolojik özellikler: Kronik B hepatiti ile karşılaştırmalı bir çalışma

Bu çalışmada kronik hepatit C (KHC) ve kronik hepatit B (KHB)'de izlenen histopatolojik özellikleri karşılaştırıp tanısal değeri olan ipuçları araştırmak amaçlandı. Kliniko-patolojik olarak KHC (n: 37) ve KHB (n: 23) tanısı konan hastaların İnterferon tedavisi öncesinde alınan biyopsi materyalleri yağlanma, asidofil cisim, safra kanalı lezyonu, sinüzoidal yangısal hücre aktivasyonu, portal lenfoid agregat ve/veya follikül oluşumu, buzlu cam hücreleri, nükleer polimorfizm, kumlu nukleus, Mallory-benzeri cisim, emperipolezis, peripolezis, hepatositlerde asidofil değişiklik ve büyük hücreli değişiklik (BHD) açısından değerlendirildi. En sık görülen özellikler KHC'de portal lenfoid agregat ve/veya follikül oluşumu (%86,48), peripolezis (%70,27), yağlanma (%51,35), asidofil cisim (%48,64), nükleer polimorfizm (%43,24), safra kanalı lezyonu (%37,83), asidofil değişiklik (%35,13), sinüzoidal yangısal hücre aktivasyonu (%35,13), KHB'de ise peripolezis (%91,30), nükleer polimorfizm (%86,9), buzlu cam hücreleri (%78,26), asidofil değişiklik (%65,21), asidofil cisim varlığı (%65,21), kumlu nukleuslar (%52,17) ve emperipolezis (%52,17) idi. KHC' inde portal lenfoid agregat ve/veya follikül oluşumu, safra kanalı lezyonu, sinüzoidal yangısal hücre aktivasyonu, KHB' de ise nükleer polimorfizm, emperipolezis, peripolezis, asidofil değişiklik ve BHD' in varlığı istatistiksel olarak anlamlı bulundu (p

Anahtar Kelimeler:

Hepatit B, kronik, Hepatit C, kronik, Patoloji, Histolojik teknikler, Histoloji, karşılaştırmalı, Biyopsi, İnterferonlar

Histopathologic features in chronic hepatitis C: A comparative study with chronic hepatitis B

The aim of this study is to compare the histopathotogic features observed in chronic hepatitis C (CHC) and chronic hepatitis B (CHB) in order to search for diagnostic clues. Liver biopsy materials, taken prior to interferon treatment from patients with clinico-pathological diagnoses of CHC (n:37) and CHB (n:23), between 1989 and 1995 were included in the study. Histopathologic examination was performed for the detection of steatosis, acidophil bodies, bile duct lesions, activation of sinusoidal inflammatory cells, lymphoid aggregates and/or follicles in portal tracts, ground glass hepatocytes, nuclear polymorphism, sanded nuclei, Mallory body-like material, emperipolesis, peripolesis, acidophilic change and large cell change (LCC) of hepatocytes. Most common features were; lymphoid aggregates and/or follicles in portal tracts (%86,48), peripolesis (%70,27), steatosis (%51,35), acidophil bodies (%48,64), nuclear polymorphism (%43,24), bile duct lesions (%37,83), acidophilic change (%35,13), activation of sinusoidal inflammatory cells (%35,13), in CHC, and peripoleis (%91,30), nuclear polymorphism (%86,9), ground glass hepatocytes (%78,26), acidophilic change (%65,21), acidophil bodies (%65,21), sanded nuclei (%52,17) and emperipolesis (%52,17) in CHS. Occurrence of lymphoid aggregates and/or follicles in portal tracts, bile duct lesions and activation of sinusoidal inflammatory cells in CHC and ground glass hepatocytes, nuclear polymorphism, emperipolesis, peripolesis, acidophilic change and LCC in CHB were found to be statistically significant (p<0,05).

Keywords:

Hepatitis B, Chronic, Hepatitis C, Chronic, Pathology, Histological Techniques, Histology, Comparative, Biopsy, Interferons,

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