Koroner arter hastalığında magnezyum/fosfat oranı ile endotel fonksiyonları arasındaki ilişki: Bir prospektif çalışma

Amaç: Aterosklerotik değişikliklerin ve endotel disfonksiyonunun patogenezi karmaşık ve çok faktörlüdür. Kandaki elektrolitlerden magnezyum ve fosfat mineralleri aterogenez ve endotel fonksiyon bozukluğunun patofizyolojisinde yer alan önemli minerallerdir. Endotel fonksiyonu değerlendirmede en çok kabul görmüş akım aracılı vazodilatasyon testidir. Çalışmamızda, koroner arter hastalığı olan hastalarda magnezyum/fosfat oranı ile endotel fonksiyonları arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Koroner anjiyografi ile belgelenmiş koroner arter hastalığı olan ardışık 61 hasta çalışmaya dahil edildi. Radial arterden akım aracılı vazodilatasyon testi ile endotel fonksiyonları poliklinik kontrolünde incelendi. Magnezyum/fosfat oranı ile akım aracılı vazodilatasyon yüzdelik değişimi arasındaki korelasyonu değerlendirmek için Spearman korelasyon analizi kullanıldı. Bulgular: Hastaların ortalama yaşı 61,2±10,1 yıl olup hastaların %72’si erkek ve ortalama vücut kitle indeksi 27,8±5,4 kg/m2’dir. AAD testinde ortalama radial arter bazal çapı 0,25±0,03 cm, test sonrası ortalama radial arter çapı 0,28±0,03 cm olarak saptandı. Magnezyum/fosfat oranları ile endotel fonksiyonlarını gösteren arter çapındaki yüzdelik değişim arasında pozitif yönde bir ilişki saptandı (r = 0,268, p = 0,037). Sonuç: Koroner arter hastalığı olan hastalarda, magnezyum/fosfat oranı endotel fonksiyonlarının bir göstergesi olarak kullanılabilir.

Relationship between magnesium / phosphate ratio and endothelial function in coronary artery disease: A prospective study

Aim: The pathogenesis of atherosclerotic changes and endothelial dysfunction is complex and multifactorial. Magnesium and phosphate minerals are important blood minerals in the pathophysiology of atherogenesis and endothelial dysfunction. Flow-mediated vasodilation test is known as one of the most valuable examination in evaluation of endothelial functions. Our study’s aim was to evaluate the relationship between magnesium / phosphate ratio and endothelial functions in patients with coronary artery disease. Materials and Methods: Sixty-one patients who had had coronary angiography and diagnosed with coronary artery disease were consecutively included. Endothelial functions were evaluated by flow-mediated vasodilation test on the radial artery during outpatient visit. Spearman correlation was used to evaluate the correlation between the Mg / P ratio and the FMD percentile change. Results: Mean age of patients was 61.2 ± 10.1 years, and 72% of the patients were male and the mean body mass index was 27.8 ± 5.4 kg/m2. In the flow-mediated vasodilation test, the mean radial artery basal diameter was 0.25 ± 0.03 cm, and the mean radial artery diameter after FMD was 0.28 ± 0.03 cm. A positive correlation was observed between magnesium / phosphate ratio and the percentage change in artery diameter implying endothelial functions (r = 0.268, p = 0.037). Conclusion: In patients with coronary artery disease, magnesium / phosphate ratios can be used as a parameter reflecting endothelial function.

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