Gökhan ALICI, Hazar HARBALIOĞLU, Ömer GENÇ, Samir ALLAHVERDİYEV, Abdullah YILDIRIM, Fahri ER, İbrahim Halil KURT, Alaa QUISI

COVID-19 tanılı yetişkinlerde yüksek duyarlıklı kardiyak troponin I ve D-dimer hastane içi mortalite için risk faktörleridir: Retrospektif kohort çalışması

COVID-19 tanılı yetişkinlerde yüksek duyarlıklı kardiyak troponin I ve D-dimer hastane içi mortalite için risk faktörleridir: Retrospektif kohort çalışması Gereç ve Yöntem: Küresel bir sağlık felaketi olan COVID-19 salgını, Aralık 2019'da ortaya çıktığından bu yana dünya çapında önemli morbidite ve mortaliteyle sonuçlanarak yavaş yavaş ülke çapında yayıldı. COVID-19 hemostatik anormallikler ve kardiyak hasar ile ilişkilidir. Bu retrospektif kohort çalışmasına toplam 221 yetişkin hasta dahil edilmiştir. COVID-19 tanısı, Dünya Sağlık Örgütü'nün geçici rehberlerine göre konuldu ve SARS-CoV-2' nin RNA tespiti ile doğrulandı. Hastalar sağ kalanlar ve sağ kalımı olmayanlar olarak 2 grupta incelendi. Bulgular: Başvuru esnasındaki hs-cTnI ve d-dimer düzeyleri sağ kalımı olmayan CoVID-19 hastalarında anlamlı olarak daha yüksekti (her biri için p

High-sensitivity cardiac troponin I and D-dimer are risk factors for in-hospital mortality of adult patients with COVID-19: A retrospective cohort study

Aim: This study aimed to evaluate the impact of high-sensitivity cardiac troponin I (Hs-cTnI) and D-dimer on in-hospital mortality of adult patients with Coronavirus disease 2019 (COVID-19). Materials and Methods: The COVID-19 outbreak, a global health disaster, has resulted in significant morbidity and mortality around the world since it emerged in December 2019. The outbreak has gradually spread nationwide. COVID-19 is associated with hemostatic abnormalities and cardiac injury. This retrospective cohort study included a total of 221 adult inpatients. The diagnosis of COVID-19 was made according to the World Health Organization's interim guideline and confirmed by RNA detection of SARS-CoV-2. Participants were divided into 2 groups, survivors and non-survivors. Results: Hs-cTnI and D-dimer levels on admission were significantly higher in non-survivors COVID-19 patients (p18.6 ng/L for hs-cTnI to predict in-hospital mortality of adult patients with COVID-19 with 100% sensitivity and 74% specificity, and a cut-off value of > 1.41 mg/L for D-dimer with 93.3% sensitivity and 71.5% specificity. Conclusion: High-sensitivity cardiac troponin I and D-dimer levels on admission predict in-hospital mortality of adult patients with COVID-19.

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