Tahir ATİK, Ferda ÖZKINAY, Suzan GÜVEN YILMAZ, Melis PALAMAR, Hüseyin ONAY

Akondroplazi olgularında ön segment ve kornea biyomekaniği

Genetik olarak tanı konmuş 4 akondroplazi olgusunun Pentacam ile elde edilmiş ön segment bulguları ve Ocular Response Analyser ile elde edilmiş kornea biyomekanik özellikleri sunulmuştur. Fibroblast growth factor receptor 3 (FGFR3) geninde p.G380R heterozigot fonksiyon kazanımı mutasyonu saptanan 4 olgu çalışmaya dahil edildi. Merkezi kornea kalınlığı bir hastanın iki gözünde normal değerlerden yüksek, korneal histerezis ve korneal rezistans faktörü iki hastanın üç gözünde eşlik eden yüksek göziçi değerleri ile normal değerlerden düşük bulundu. Sonuç olarak, FGFR3 etkilenmesinin akondroplazi hastalarında merkezi kornea kalınlığı, korneal histerezis ve korneal rezistans faktörü değerlerinde değişikliklere yol açabileceği öngörüldü.

Anterior segment and corneal biomechanics of achondroplasia patients

Herein the anterior segment findings with Pentacam and corneal biomechanics with Ocular Response Analyser of 4 genetically proven cases of achondroplasia are reported. Four patients with heterozygous gain of function p.G380R mutation in fibroblast growth factor receptor 3 (FGFR3) gene were evaluated. Central corneal thickness was higher than normal in both eyes of one patient, and corneal hysteresis and corneal resistance factor was lower in three eyes of two patients with accompanying high intraocular pressure readings. As a result, the affection of FGFR3 in achondroplasia patients might cause changes in central corneal thickness, corneal hysteresis and corneal resistance factor.

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