Ahmet Faruk KIROĞLU, MEHMET ASLAN, MAHFUZ TURAN, Muzaffert ARI, UFUK DÜZENLİ, NAZİM BOZAN

The relationship between the ABO blood group and tumor diameters in patients with carotid body tumors

Several studies have assessed the association between blood group of ABO and many cancer types. Nevertheless, there was no data regarding the connection between blood group of ABO and tumor diameters in carotid body tumors (CBTs) patients. The purpose of our study was to analyse possible association between tumor diameters and gender, ABO blood group in CBTs patients compared to healthy controls. The demographic and laboratory data of 65 CBTs patients (57 females and 8 males) who underwent surgical intervention and 65 healthy controls (52 females and 13 males) were retrospectively analyzed. The mean age of CBTs patients was 51.81±9.82 years, and the mean age of the healthy subjects was 52.72±8.50 years. There were no statistically significant difference between two groups with regard to age and gender. The mean of tumor diameters was 3.72±1.50 cm (range=1-8 cm). There was no statistically significant difference between study groups according to AB0 blood group (p=0.87). The females/males ratio of patients was 57/8. The mean tumor diameters of females was 3.57±1.34 cm and the mean tumor diameters of males was 4.77±2.16 cm; the difference was statistically significant (p=0.03). There was a positive correlation between male gender and the tumor diameters (r=0.23, p=0.03). This is the first report investigating association between the tumor diameters and AB0 blood group in CBTs . Although CBTs were shown higher in females, tumor diameters were found significantly higher in males tha n females. However, we did not determine any association between AB0 blood group and tumor diameters.

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1. Sajid MS, Hamilton G, Baker DM. Joint Vascular Research Group. A multicenter review of carotid body tumour management. Eur J Vasc Endovasc Surg 2007; 34: 127-130.

2. Del Guercio L, Narese D, Ferrara D, Butrico L, Padricelli A, Porcellini M. Carotid and vagal body paragangliomas. Transl Med UniSa 2013; 6: 11-15.

3. Nazari I, Aarabi Moghaddam F, Zamani MM, Salimi J. Clinical characteristics and remedies in 45 Iranians with carotid body tumors. Acta Med Iran 2012; 50: 339-343.

4. Zeng G, Zhao J, Ma Y, Huang B, Yang Y, Feng H. A comparison between the treatments of functional and nonfunctional carotid body tumors. Ann Vasc Surg 2012; 26: 506-510.

5. Saldana MJ, Salem LE, Travezan R. High altitude hypoxia and chemodectomas. Hum Pathol 1973; 4: 251-263.

6. Kay JM, Laidler P. Hypoxia and the carotid body. J Clin Pathol Suppl (R Coll Pathol). 1977; 11: 30-44.

7. Aird I, Bentall HH, Roberts JA. A relationship between cancer of stomach and the ABO blood groups. Br Med J 1953; 1: 799-801.

8. Hakomori S. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta 1999; 1473: 247-266.

9. Hakomori S. Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines. Adv Exp Med Biol 2001; 491: 369-402.

10. Ma D, Liu M, Yang H, Ma X, Zhang C. Diagnosis and surgical treatment of carotid body tumor: A report of 18 cases. J Cardiovasc Dis Res 2010; 1: 122-1224.

11. Gad A, Sayed A, Elwan H, et al. Carotid Body Tumors: A Review of 25 Years Experience in Diagnosis and Management of 56 Tumors. Ann Vasc Dis 2014; 7: 292-299.

12. Georgiadis GS, Lazarides MK, Tsalkidis A, Argyropoulou P, Giatromanolaki A. Carotid body tumor in a 13-year-old child: Case report and review of the literature. J Vasc Surg 2008; 47: 874-880.

13. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883-899.

14. Wang DS, Wang ZQ, Zhang L, et al. Are risk factors associated with outcomes in pancreatic cancer? PLoS One 2012; 7: e41984.

15. Boscarino G, Parente E, Minelli F, Ferrante A, Snider F. An evaluation on management of carotid body tumour (CBT). A twelve years experience. G Chir 2014; 35: 47-51.

16. Galyfos G, Stamatatos I, Kerasidis S, et al. Multidisciplinary management of carotid body tumors in a Tertiary Urban Institution. Int J Vasc Med 2015; 2015: 969372.

17. Zhang BL, He N, Huang YB, Song FJ, Chen KX. ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev 2014; 15: 4643-4650.