The Relationship Between Placental Elasticity and Prenatal Serum Screening Markers and Doppler Indices

It has been shown that placental elasticity values were higher in pregnant women with preeclampsia and intrauterine growth restriction. The studies have been reported that prenatal serum screening markers and uterine artery Doppler parameters could be useful in the prediction of preeclampsia and intrauterine growth restriction. In this study, we aimed to investigate the relationship between placental elasticity values and these serum markers and Doppler indices in the first and second-trimester. 108 cases between 11-14 gestational weeks were enrolled for this study. Placental elasticity measurements were performed after the first-trimester combined test and Doppler assessment. The same procedures were repeated with the second-trimester triple test for 71 pregnant women who were followed-up. Correlation analysis of demographic characteristics, biochemical parameters and Doppler findings with placental elasticity values were performed. In the first-trimester, we found a statistically significant and positive correlation between placental elasticity values and bilateral uterine artery notching (r =0.193, p =0.045) and mean arterial pressure (r =0.398, p

___

1. Wald NJ, Cuckle H. Maternal serum alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Report of the U.K. Collaborative Study on Alpha-Fetoprotein in Relation to Neural-Tube Defects. Lancet 1977; 1323-1332.

2. Cuckle H, Maymon R. Development of prenatal screening--A historical overview. Semin Perinatol 2016; 40: 12-22.

3. Akolekar R, Syngelaki A, Poon L, Wright D, Nicolaides KH. Competing risks model in early screening for preeclampsia by biophysical and biochemical markers. Fetal Diagn Ther 2013; 33: 8-15.

4. Sirikunalai P, Wanapirak C, Sirichotiyakul S, et al. Associations between maternal serum free beta human chorionic gonadotropin (β-hCG) levels and adverse pregnancy outcomes. J Obstet Gynaecol 2016; 36: 178-182.

5. Audibert F, Benchimol Y, Benattar C, Champagne C, Frydman R. Prediction of preeclampsia or intrauterine growth restriction by second trimester serum screening and uterine Doppler velocimetry. Fetal Diagn Ther 2005; 20: 48-53.

6. Long W, Zhou Q, Wang H, et al. Second-trimester Maternal Serum Screening Biomarkers in the Risk Assessment for Preeclampsia. Ann Clin Lab Sci 2018; 48: 308-313.

7. Velauthar L, Plana MN, Kalidindi M, et al. First-trimester uterine artery Doppler and adverse pregnancy outcome: a meta-analysis involving 55 974 women. Ultrasound Obstet Gynecol 2014; 43: 500-507.

8. Karagiannis G, Akolekar R, Sarquis R, Wright D, Nicolaides KH. Prediction of small-for-gestation neonates from biophysical and biochemical markers at 11–13 weeks. Fetal Diagn Ther 2011; 29: 148-154.

9. Ferraioli G, Maiocchi L, Lissandrin R, Tinelli C, De Silvestri A, Filice C. Accuracy of the ElastPQ technique for the assessment of liver fibrosis in patients with chronic hepatitis C: a "Real life" single center study. J Gastrointestin Liver Dis 2016; 25: 331-335.

10. Karaman E, Arslan H, Çetin O, et al. Comparison of placental elasticity in normal and pre-eclamptic pregnant women by acoustic radiation force impulse elastosonography. J Obstet Gynaecol Res 2016; 42: 1464-1470.

11. Akbas M, Koyuncu FM, Artunç-Ulkumen B. Placental elasticity assessment by point shear wave elastography in pregnancies with intrauterine growth restriction. J Perinat Med 2019; 47: 841-846.

12. Yuksel MA, Kilic F, Kayadibi Y, et al. Shear wave elastography of the placenta in patients with gestational diabetes mellitus. J Obstet Gynaecol 2016; 36: 585-588.

13. Cetin O, Karaman E, Arslan H, Akbudak I, Yıldızhan R, Kolusarı A. Acoustic radiation force impulse elastosonography of placenta in maternal red blood cell alloimmunization: a preliminary and descriptive study. Med Ultrason 2017;19: 73-78.

14. Barr RG, Nakashima K, Amy D, et al. WFUMB guidelines and recommendations for clinical use of ultrasound elastography. Ultrasound Med Biol 2015; 41: 1148-1160.

15. Ferraioli G, Filice C, Castera L, et al. WFUMB guidelines and recommendations for clinical use of ultrasound elastography. Ultrasound Med Biol 2015; 41: 1161-1179.

16. Sigrist R, Liau J, Kaffas AE, Chammas MC, Willmann JK. Ultrasound elastography: review of techniques and clinical applications. Theranostics 2017; 7: 1303-1329.

17. Herman BA, Harris GR. Models and regulatory considerations for transient temperature rise during diagnostic ultrasound pulses. Ultrasound Med Biol 2002; 28: 1217-1224.

18. Sugitani M, Fujita Y, Yumoto Y, et al. A new method for measurement of placental elasticity: acoustic radiation force impulse imaging. Placenta 2013; 34: 1009-1013.

19. Poon LC, Nicolaides KH. First-trimester maternal factors and biomarker screening for preeclampsia. Prenat Diagn 2014; 34: 618-627.

20. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350: 672-683.

21. Cnossen JS, Morris RK, ter Riet G, et al. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 2008; 178: 701-711.

22. Arioz Habibi H, Alici Davutoglu E, Kandemirli SG, et al. In vivo assessment of placental elasticity in intrauterine growth restriction by shear-wave elastography. Eur J Radiol 2017; 97: 16-20.

23. Kılıç F, Kayadibi Y, Yüksel MA, et al. Shear wave elastography of placenta: in vivo quantitation of placental elasticity in preeclampsia. Diagn Interv Radiol 2015; 21: 202-207.

24. Akolekar R, Syngelaki A, Sarquis R, Zvanca M, Nicolaides KH. Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11–13 weeks. Prenat Diagn 2011; 31: 66-74.

25. Kuc S, Koster MP, Franx A, Schielen PC, Visser GH. Maternal characteristics, mean arterial pressure and serum markers in early prediction of preeclampsia. PLoS One 2013; 8: 63546.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

Clinical and Pathological Predictors of Prolonged Lymphorrhoea After Pelvic Lymph Dissection in Radical Cystectomy

Orkunt ÖZKAPTAN, Muhsin BALABAN, Alkan ÇUBUK, Ahmet ŞAHAN, Kasım ERTAŞ, Cüneyd SEVİNC, Tahir KARADENİZ

Thoracopagus: A Case of Conjoined Twins

Gökçe Naz KÜÇÜKBAŞ, Gurcan TURKYILMAZ, Güler ŞAHİN

Is Laparoscopic Cholecystectomy a Safe Method For Elderly Patients? A Retrospective Clinical Study

Feyzi KURT

The Association of Visfatin Levels With Metabolic Parameters and Inflammation In Diabetic Nephropathy

Ayşegül SAKİN, Süleyman ŞAHİN, Ahmet BEHLUL, Abdullah SUMNU, Meltem GÜRSU, Abdullah SAKİN, Savas OZTURK

Incidentally Detection of the Swyer-James Syndrome With Opposite Side Pneumonia

Guner DEMİR, Mehmet ASLAN

Orthodontic Camouflage Treatment of Skeletal Class III Malocclusion with Mandibular Bite Turbo Application

Saadet CINARSOY CIGERIM

Selecting The Arterial Cannulation Site In Acute Type A Aortic Dissection: Axillary Artery Or Femoral Artery?

Şahin ŞAHİNALP, Ali Kemal GÜR

The Relationship Between Placental Elasticity and Prenatal Serum Screening Markers and Doppler Indices

Murat AKBAŞ, Faik Mümtaz KOYUNCU, Hakan ERENEL, Burcu ARTYNC ULKUMEN, Tülay OLUDAĞ METE

Preoperative Factors Associated with the Need for the Morcellation in Total Laparoscopic Hysterectomy

Hüseyin KIYAK, Onur KARAASLAN, Kerem SEÇKİN, Tolga KARACAN, Eser Sefik OZYUREK, Gulseren YILMAZ, Berk BULUT

A Case of Lung Adenocarcinoma Presenting as Miliary Appearance

Buket Mermit ÇİLİNGİR, Aysel SUNNETCİOGLU, Mesut ÖZGÖKÇE, İrfan BAYRAM