Toprak Streptomyces İzolatlarının Cryptococcus neoformans Kültürlerine Karşı Antifungal Aktivitesi

Bu çalışmada, Düzce ili topraklardan elde edilen 128 farklı Streptomyces izolatlarının % 26,5'inin Cryptococcus neoformans ATCC 90112 mayasına karşı antifungal aktivite gösterdiği saptanmıştır. Agar plağında oluşan inhibisyon bölgesinin çapı dikkate alınarak izolatlar dört bölüme ayrılmıştır. Buna göre, bölüm 1 (5-10 mm, hafif aktif); bölüm 2 (11-15 mm, orta derecede aktif), bölüm 3 (16-25 mm, yüksek derecede aktif) ve bölüm 4 (26-35 mm, ultra aktif) olarak belirlenmiştir. Bölüm 4'teki 3 izolatın ise kriptokokkoz hastalığına karşı yeni bir antibiyotik kaynağı olabileceği saptanmıştır.

Anahtar Kelimeler:

Streptomyces, Antifungal Aktivite, Cryptococcus neoformans

Antifungal Activity of Soil Streptomyces Isolates Against Cryptococcus neoformans

In this study, 26.5% of 128 different isolates of Streptomyces recovered from soils in Duzce province, Turkey showed antifungal activity against Cryptococcus neoformans ATCC 90112. Considering the diameter of the inhibition zone formed on the agar plate, isolates were divided into four sections: section 1 (5-10 mm, slightly-active); section 2 (11-15 mm, moderately-active), section 3 (16-25 mm, highly-active) and section 4 (26-35 mm, ultra-active). It is determined that 3 isolates in section 4 may be a source of novel antibiotic against Cryptococcosis.

Keywords:

Streptomyces, Antifungal Activity, Cryptococcus neoformans,

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