Patolojik İki Taraflı İntraserebral Kalsifikasyonlar: Nörolojik ve Psikiyatrik Değerlendirme

Bazal gangliyonlar, serebral hemisfer beyaz cevherinde ve serebellumun dentat nükleuslarında bilateral kalsifikasyonlar veya diğer minerallerin depolanması nadir bir hastalıktır. Hipoparatiroidizm ve idyopatik striopallido-dentat kalsinoz (Fahr hastalığı) patolojik intraserebral kalsifikasyonların en sık rastlanan iki sebebidir. Bu hastalarda hareket bozuklukları en sık rastlanan bulgudur. Kalsifikasyonlara eşlik eden nörolojik ve psikiyatrik bozukluklar tartışıldığı bu makalede, literatürden farklı olarak nöbetlerin ve başağrısı problemlerinin bizim hastalarımızda baskın olması dikkat çekiciydi

Bilateral Pathological Intracerebral Calcifications: Neurological and Psychiatric Evaluation

Bilateral, symmetric, calcium and other mineral deposits occur in basal ganglia, thalamus, cerebellum, and white matter off cerebral hemisphere are rare disorders. Hypoparathyroidism and Fahr’s disease (progressive idiopathic strio-pallidodentat calsinozis) are the most common two pathologies in etiology of bilateral calcifications. Extrapyramidal problems are the most commonly seen clinical finding in these patients. In this article in which neurological and psychiatric disorders in relation to calcifications were discussed, seizures and headache problems were more prominent in our patients

___

  • Rastogi R, Norman J, Ladenson BPW. Calcifications of the Basal Ganglia in Chronic Hypoparathyroidizm. The Journal of Clinical Endocrinology and Metabolism 88:1476- 1477, 2003
  • Özer T, Savranlar A, Bayraktaroğlu T, Asil K. İntracranial calcifications due to hypopara- thyroidism after thyroidectomy. Nörol Bil Dergisi. 21:4-7, 2004
  • Jorens PG, Appel BJ, Hilte FA, Mahler C, De Deyn PP. Basal ganglia calcifications in postoperative hypoparathyroidism;a case with unusual characteristics.Acta Neurol Scand. 83:137-140, 1991
  • Lang C, Huk W, Pichl J. Comparison of extensive brain calcification in postoperative hypoparathyoidism on CT and NMR scan. Neuroradiology 31:29-32. 1989
  • Avrahami E, Cohn DF, Feibel M, Tadonor R. MRI demonstation and CT correlation of the brain in patients with idiopathic intracerebral calcification.J.Neurol 241:381-384. 1994
  • Oot RF, New PF, Pile Spellman J, Rosen BR, Shoukimas GM, Davis KR. The detection of intracranial calcifications by MR.AJNR Am J Neuroradial 7:801-809. 1986
  • Özcan C, Bölük A, Bereketoğlu MA, Ekmekçi H, Saraç K, Yılmaz H. Fahr’s syndrome (idiopathic bilateral striopallido- dentate calcification): case report. Journal of Inonu University Medical Faculty, Volum 1, No.4. 1994
  • Scotti G, Scialfa G, Tampieri D, Landoni L. MR imaging in Fahr disease. J Comput Assist Tomogr 9:790-792. 1985
  • Yoshikawa H, Abe T. Transient parkinsonism in bilateral striopallido- dentate calcinosis. Pediatr Neurol 29:75-77. 2003
  • Hanağası H, Hanağası F, Bilgiç B. Bilateral striopallidodentat kalsinosis’in klinik spektrumu. Türk Nöroloji Dergisi 5:430-437, 2004
  • Avrahami E, Cohn DF, Feibel M, Tadmor R. MRI demonstration and CT correlation of the brain in patients with idiopathic intracerebral calcification. J Neurol 241:381-384, 1994
  • Duckett S, Galle P, Escourolle R, Poirier J, Hauw JJ. Presence of zinc, aluminum, magnesium in striopalledodentate (SPD) calcifications (Fahr's disease): electron probe study. Acta Neuropathol 38:7-10, 1977
  • 13.Kozik M, Kulczycki J. Laser- spectrographic analysis of the catian content in Fahr Syndrome. Arch Psychiart 225:135- 142, 1978
  • Bouras C, Giannakopoulos P, Good PF, Hsu A, Hof PR, Perl DP. A laser microprobe mass analysis of trace elements in brain mineralizations and capillaries in Fahr's disease. Acta Neuropathol 92:351-357, 1996
  • Manyam BV, Walters AS, Keller LA, Ghobrial M. Parkinsonism associated with autosomal dominant bilateral striopallido- dentate calcinosis. Parkinsonism Relat Disord 7:289-295, 2001
  • Manyam BV, Walters AS, Narla KR. Bilateral striopallidodentate calcinosis: clinical characteristics of patients seen in a registry. Mov Disord 16:258-264, 2001
  • Ring HA, Serra-Mestres J: Neuropsychiatry of the basal ganglia.J Neurol Neurosurg Psychiatry 72:12–21, 2002
  • Mega MS, Cummings JL: Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 6:358–370, 1994
  • Cartier L, Passig C, Gormaz A, Lopez J. Neuropsychological and neurophysiological features of Fahr's disease Rev Med Chil 130:1383-1390, 2002
Düzce Tıp Fakültesi Dergisi-Cover
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1999
  • Yayıncı: Düzce Üniversitesi Tıp Fakültesi