Fahrettin YILDIZ, Sacit ÇOBAN, Abdullah TAŞKIN, Muharrem BİTİREN, Nurten AKSOY, Alpaslan TERZİ

Karaciğer İskemi Reperfüzyon Hasarı Yapılan Sıçanlarda Urtica dioica’nın Karaciğer Üzerine Koruyucu Etkisi

Amaç: Karaciğer iskemi reperfüzyon hasarı yapılan sıçanlarda Urtica dioica’nın karaciğerdokusuna koruyucu etkilerini araştırmak amacıyla bu çalışmayı planladık. Gereç ve Yöntem: Çalışmamızda toplam 30 adet Wistar-albino sıçan kullanıldı. Sıçanlar, operesham grup (Grup1), kontrol grup (Grup2) ve Urtica dioica tedavi grubu(Grup3) olarak 3 eşitgruba ayrıldı. Tedavi grubuna iskemiden hemen önce ve reperfüzyondan hemen sonra 2 ml/kgintraperitoneal olarak Urtica dioica verildi. Karaciğer dokusunda total antioksidan kapasite, totalfree sülfidril grup, total oksidan durum, oksidatif stress indeksi ve myeloperoksidaz seviyeleriölçüldü. Ayrıca serumda ALT, AST ve LDH seviyeleri ölçüldü.Bulgular: Karaciğer dokusunda total antioksidan kapasite ve total free sülfidril grup değerleritedavi grubunda kontrol grubuna göre anlamlı derecede artmıştı. (p

Anahtar Kelimeler:

Urtica dioica, Karaciğer İskemi Reperfüzyon, Oksidan Durum

Protective Effect of Urtica dioica on Liver Injury Induced by Hepatic Ischemia Reperfusion Injury in Rats

Background: This study was designed to investigate the effects of Urtica dioica on liverischemia reperfusion injury in rats. Methods: Thirty male Wistar-albino rats were used in this experimental study. Animals weredivided into three groups as sham operated (group 1), control (group 2), and Urtica dioicatreatment group (group 3). Urtica dioica 2ml/kg were administered intraperitoneally beforeischemia and immediately after the reperfusion. The levels of total antioxidant capacity, totalfree sulfidril group, Total oxidant status, Oxidative stress index, and myeloperoxidase in livertissues were measured. The serum levels of ALT, AST and LDH were also measuredResults: Total antioxidant capacity and total free sulfidril group in liver tissue were significantlyhigher in group 3 than in group 2. Oxidative stress index and myeloperoxidase in liver tissuewere significantly lower in group 3 than the group 2. The levels of liver enzymes in treatmentgroup were significantly lower than those in the control group. Histological tissue damage wasmilder in the treatment group than that in the control group.Conclusion: It is concluded that Urtica dioica increase the antioxidant capacity and decreaseoxidative stress and liver enzymes in the hepatic ischemi reperfusion injury of rats

Keywords:

Urtica dioica, Hepatic Ischemia Reperfusion, Oxidative status,

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