Mesut GÜLER, Erdinç TÜRKELİ, Ebubekir ŞERAMET, Ali DOĞAN, Mustafa USLU

İloprostun Diz Eklem Snovyası Ve Kıkırdağı Üzerindeki Etkileri

Amaç: Bu çalışmada iloprostun kıkırdak ve sinovya üzerine olan etkilerini göstermek içinyapılmıştır.Materyal metod: Çalışmada iloprost’un diz eklemi kıkırdak ve sinovya üzerine olan etkileri;yavru erkek Spraque-Dawley cinsi sıçanlar üzerinde histopatolojik olarak araştırılmıştır. 20adet sıçan rastgele olarak 5’erli 4 gruba ayrılmıştır. Bütün sıçanların sol dizlerine 0,1 ml iloprost,sağ dizlerine 0,1 ml eklem içi serum fizyolojik verilmiştir. Her gurup sırasıyla 1. gün, 7. gün,14. gün, 21. günlerde kurban edilerek; diz eklemlerinin femur kondilleri, tibia üst uçları vekapsülü de içerecek şekilde kesilerek histopatolojik olarak incelendi.Bulgular: Histopatolojik inceleme sonucunda; iloprost verilen dizler ile konrol grubu dizlerarasında istatiksel olarak anlamlı farklar bulundu. İloprost grubunda eklem kıkırdağında vesinovyada yangının erken kurban edilen edilen sıçanlarda daha fazla olduğu zamanla kontrolgrubu ile arasındaki farkın kapandığı görülmüştür. Sinovya hipertrofi ve sinovya hiperplaziincelemesinde ise iloprost ve kontrol grubuyla fark olduğu ve bu farkın zamanla değişmediğigörülmüştür.Sonuç: İloprostun eklem içindeki yangısal olayları arttırdığı gözlendiği için eklem içine direktenjeksiyon şeklinde verilmemesi gerektiği sonucuna varılmıştır. Sistemik verilecek iloprostunosteoartritli dizlerde olumlu etkiler yapabileceği düşünülmüştür

Anahtar Kelimeler:

İloprost, sıçan, diz eklemi, kıkırdak, snovya

The Effect Of Iloprost On Joint Synovium And Cartilage

Purpose: This study is performed to identify the effect of iliprost on joint synovium andcartilage.Material and method: In this study histopathological evaluation of iloprost effects on kneejoint synovium and cartilage are determined on young male Spraque-Dawley rats. Twenty ratsdivided into four groups, each consisted five rats. 0.1 ml iloprost enjected into right knees and0.1 ml SF enjected into left knees of all rats. The groups are sacrificed randomly on first, seventh,fourteenth and twentyfirst days. Knee specimens are taken including femoral condyles, tibialplatos and capsules for histopathological evaluation.Result: At the end of the histopathological evaluation, there was significant difference betweenthe knees iloprost injected group and SF injected, control group. İn the early sacrifeced iloprostgroup, inflammation on joint cartilage and synovium is much more than late sacrifeced iloprostgroups. İnflammation between the iloprost groups and SF control goups decreased timedepentently. İn the synovial hyperplasia and synovial hypertrophy there was significantdifference between the iloprost group and SF group and not changed time dependently.Conclusion: As intraarticular injected iloprost increased intraarticular inflammation we shoulddecided not to give iloprost intraarticularly. İt is thought that systemic iloprost will have positiveeffects on osteoarthritic knees

Keywords:

Iloprost, rat, knee joint, cartilage, synovium,

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