Vahap Ozan KOTAN, Fatma Meriç YILMAZ, SALİM NEŞELİOĞLU, ÖZCAN EREL, İhsan Tuncer OKAY, Serkan KİRAL, Abdurrahim BAKİRHAN, Erol GÖKA

Thiol/Disulphide Homeostasis in Men with Heroin Addiction

Eroin bağımlılığının oksidatif stres artışı ile ilişkili olduğu bilinmektedir. Oksidatif stres disülfit oluşumuna yol açarak tiol/disülfit (SH/SS) homeostazını bozabilir ve böylece protein işlevlerinde değişimlere neden olabilir. Eroin bağımlılarında serum tiol miktarı ve kan disülfit miktarının araştırıldığı bir çalışma mevcut değildir. Bu çalışmanın amacı eroin bağımlılığında dinamik SH/SS homeostazını incelemektir. Yöntem: Otuz bir eroin bağımlısı erkek ve otuz bir sağlıklı erkekte natif tiol-disülfit değişimlerini içeren kan SH/SS homeostazı incelendi. Serum natif tiol ve total tiol (ToSH) düzeyleri ölçüldü; natif tiol ve ToSH düzeyleri farkının yarı değeri olarak disülfit bağ düzeyi hesaplandı. Karşılaştırmalar t testi ile yapıldı.Bulgular: Eroin bağımlısı erkeklerde SH ve ToSH konsantrasyonları kontrollere göre daha düşük (her ikisi için p

Eroin bağımlısı erkeklerde tiol/disülfit homeostaz

Heroin addicts have increased oxidative stress which can disturb thiol/disulfide (SH/SS) homeostasis, causing disulfide formation. No study has determined the serum thiol amount and blood disulfide amount in heroin addicts. The aim of the study was to investigate dynamic SH/SS homeostasis in heroin addicts.Methods: Serum SH/SS statuses of 31 heroin addicts and 31 healthy controls were compared to determine the changes in SH/SS homeostasis in heroin addicts. Blood serum native thiol and total thiol (ToSH) levels were measured and the disulfide bond amount was calculated as the half value of the difference between native thiol and ToSH levels. For comparison t-test was used.Results: SH and ToSH levels were significantly lower (p

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