Yavuz ALTUNKAYNAK, Musa ÖZTÜRK, Devrimsel Harika ERTEM, Betül GÜVELİ, Filiz OKAY UZUN, Zerrin YILDIRIM, Belgin MUTLUAY, Ayten DİRİCAN CEYHAN, Emine ALTUNKAYNAK, AYHAN KÖKSAL, Sevim BAYBAŞ

Serum lactic acid and pyruvic acid levels in patients with migraine and tension type headache

Amaç: Bir mitokondriyal sitopati olan MELAS (Mitokondriyal miyopati, ensefalopati, laktik asidoz ve inme benzeri epizotlar) sendromuna migren tipi baş ağrıları sıklıkla eşlik eder. Bu nedenle, migren ile mitokondriyal bozukluklar arasındaki ilişki ilgi çekicidir. Ayrıca gerilim tipi baş ağrılarında da mitokondriyal anormallikler incelenmektedir. Biz de migrenli ve gerilim tipi baş ağrılarında mitokondriyal bozukluk varlığını araştırmak amacıyla serum laktik ve pirüvik asit düzeylerini ölçmeyi ve bu değerleri sağlıklı kontrol grubuyla karşılaştırmayı amaçladık. Yöntem: Çalışmaya, Uluslararası Baş Ağrısı Topluluğu’nun (IHS) 2004 sınıflama sistemine göre tanı almış 30 migrenli, 30 gerilim tipi baş ağrılı hasta ve 30 sağlıklı kontrol alındı. Çalışmaya katılanlardan alınan örneklerde serum laktik ve pirüvik asit düzeyleri biyokimyasal yöntemlerle çalışıldı. İstatistiksel analizler için SPSS programında Kruskal-Wallis Testi ve Mann-Whitney testleri kullanıldı. Bulgular: Migren ve gerilim tipi baş ağrısı olan hastaların serum laktik ve pirüvik asit düzeyleri, kontrol grubuyla karşılaştırıldığında anlamlı olarak yüksek bulundu. Sonuç: Migrenli ve gerilim tipi baş ağrılı hastalarda mitokondriyal bozuklukların araştırılması için geniş çaplı multidisipliner araştırmalar gereklidir.

Migren tipi ve gerilim tipi baş ağrıları bulunan hastalarda pirüvik ve laktik asit seviyeleri

Objective: MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is frequently associated with migraine like headaches. The relationship between migraine and mitochondrial diseases is interesting. Also mitochondrial disorders in tension like headache still remain to be investigated. The aim of this report is to evaluate the serum lactic acid and pyruvic acid levels in patients with migraine and tension type headache and compare them with healthy control group. Methods: We evaluated 30 patients with migraine, 30 patients with tension like headache and 30 healthy control. Lactic and pyruvic acid levels in serum samples were measured by biochemical methods. Kruskal Wallis and Mann-Whitney tests were used for statistical analysis using SPSS 11.5 for Windows program. Results: Serum lactic and pyruvic acid levels in patients with migraine and tension type headache were significantly higher than control group. Conclusion: Multi-disciplinary researches are needed to determine mitochondrial diseases in patients with migraine and tension like headache.

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