Mirtazapin ilişkili manik / hipomanik kayma: Mini derleme ve olgu sunumu
Mirtazapin hem antidepresan olarak hem de hipnotik sedatif etkisi nedeni ile sıkça kullanılan bir farmakolojik ajandır. Ancak diğer antidepresanlarda önemli bir yan etki olan manik kayma, mirtazapin tedavisinde yeterince ele alınmamış, kanıtlar genellikle olgu sunumu aşamasında kalmıştır. Bu mini-derleme ve olgu sunumunda mirtazapinle ilişkili manik kayma ile ilgili olgu sunumlarını derleyerek, bu olgulara göre çok daha kısa sürede manik kaymanın izlendiği bir vakanın sunulması planlanmıştır.
Mirtazapine-related manic / hypomanic shift: mini review and case report
Mirtazapine is a pharmacological agent frequently used both as an antidepressant and as a hypnoticsedative agent. However, manic shift, an important side effect of other antidepressants, has not beenadequately addressed in the treatment of mirtazapine, and the evidence has been only available fromcase reports. This mini-review and case report aimed to compile case reports on mirtazapine related manicshifts and to report a case where a manic shift was determined relatively early compared to that in thesecases.
___
- de Boer T. The effects of mirtazapine on central noradrenergic
and serotonergic neurotransmission. Int Clin Psychopharmacol
1995; 10(Spull.4):19-23.
- Wichniak A, Wierzbicka A, Jernajczyk W. Sleep and antidepressant
treatment. Curr Pharm Des 2012; 18:5802-5817. [CrossRef]
- Wichniak A, Wierzbicka A, Jernajczyk W. Sleep and antidepressant
treatment. Curr Pharm Des 2012; 18:5802-5817. [CrossRef]
- Allain N, Leven C, Falissard B, Allain JS, Batail JM, Polard E,
Montastruc F, Drapier D, Naudet F. Manic switches induced
by antidepressants: an umbrella review comparing randomized
controlled trials and observational studies. Acta Psychiatr Scand
2017; 135:106-116. [CrossRef]
- Koszewska I, Rybakowski JK. Antidepressant-induced mood
conversions in bipolar disorder: a retrospective study of tricyclic
versus non-tricyclic antidepressant drugs. Neuropsychobiology
2009; 59:12-16. [CrossRef]
- Post RM, Altshuler LL, Leverich GS, Frye MA, Nolen WA, Kupka
RW, Suppes T, McElroy S, Keck PE, Denicoff KD, Grunze
H, Walden J, Kitchen CM, Mintz J. Mood switch in bipolar
depression: comparison of adjunctive venlafaxine, bupropion
and sertraline. Br J Psychiatry 2006; 189:124-131. [CrossRef]
- Pacchiarotti I, Bond DJ, Baldessarini RJ, Nolen WA, Grunze
H, Licht RW, Post RM, Berk M, Goodwin GM, Sachs GS,
Tondo L, Findling RL, Youngstrom EA, Tohen M, Undurraga J,
González-Pinto A, Goldberg JF, Yildiz A, Altshuler LL, Calabrese
JR, Mitchell PB, Thase ME, Koukopoulos A, Colom F, Frye MA,
Malhi GS, Fountoulakis KN, Vázquez G, Perlis RH, Ketter TA,
Cassidy F, Akiskal H, Azorin JM, Valentí M, Mazzei DH, Lafer
B, Kato T, Mazzarini L, Martínez-Aran A, Parker G, Souery
D, Ozerdem A, McElroy SL, Girardi P, Bauer M, Yatham LN,
Zarate CA, Nierenberg AA, Birmaher B, Kanba S, El-Mallakh RS,
Serretti A, Rihmer Z, Young AH, Kotzalidis GD, MacQueen GM,
Bowden CL, Ghaemi SN, Lopez-Jaramillo C, Rybakowski J, Ha
K, Perugi G, Kasper S, Amsterdam JD, Hirschfeld RM, Kapczinski
F, Vieta E. The International Society for Bipolar Disorders (ISBD)
task force report on antidepressant use in bipolar disorders. Am
J Psychiatry 2013; 170:1249-1262. [CrossRef]
- Benazzi F. Antidepressant-associated hypomania in outpatient
depression: a 203-case study in private practice. J Affect Disord
1997; 46:73-77. [CrossRef]
- Boerlin HL, Gitlin MJ, Zoellner LA, Hammen CL. Bipolar
depression and antidepressant-induced mania: a naturalistic
study. J Clin Psychiatry 1998; 59:374-379. [CrossRef]
- De León OA, Furmaga KM, Kaltsounis J. Mirtazapine-induced
mania in a case of poststroke depression. J Neuropsychiatry Clin
Neurosci 1999; 11:115-116. [CrossRef]
- Wichniak A, Jarkiewicz M, Okruszek Ł, Wierzbicka A, Holka-
Pokorska J, Rybakowski J. Low risk for switch to mania
during treatment with sleep promoting antidepressants.
Pharmacopsychiatry 2015; 48:83-88. [CrossRef]
- Basavraj V, Nanjundappa GB, Chandra PS. Mirtazapine induced
mania in a woman with major depression in the absence of
features of bipolarity. Aust N Z J Psychiatry 2011; 45:901-902.
[CrossRef]
- Liu CC, Liang KY, Liao S-C. Antidepressant-associated mania:
soon after switch from fluoxetine to mirtazapine in an elderly
woman with mixed depressive features. J Psychopharmacol
2009; 23:220-222. [CrossRef]
- Habermeyer B, Bayer U, Müller-Spahn F. Mania associated with
mirtazapine treatment and mixed depression. Pharmacopsychiatry
2010; 43:37-38. [CrossRef]
- Bhanji NH, Margolese HC, Saint-Laurent M, Chouinard G.
Dysphoric mania induced by high-dose mirtazapine: a case for
‘norepinephrine syndrome’? Int Clin Psychopharmacol 2002;
17:319-322. [CrossRef]
- Prost E, Abraham G. Mirtazapine-induced shopping spree. Can J
Psychiatry 2004; 49:495. [CrossRef]
- Ng B. Mania associated with mirtazapine augmentation of
fluoxetine. Depress Anxiety 2002; 15:46-47. [CrossRef]
- Soutullo CA, McElroy SL, Keck PE Jr. Hypomania associated
with mirtazapine augmentation of sertraline. J Clin Psychiatry
1998; 59:320. [CrossRef]
- Goyal N, Sinha VK. Mirtazapine-induced manic switch in
adolescent unipolar depression. Aust N Z J Psychiatry 2008;
42:1070-1071.
- MacCall C, Callender J. Mirtazapine withdrawal causing
hypomania. Br J Psychiatry 1999; 175:390. [CrossRef]
- Verma JK, Mohapatra S. Mirtazapine withdrawal-induced mania.
J Pharmacol Pharmacother 2015; 6:214-215. [CrossRef]
- Viktorin A, Lichtenstein P, Thase ME, Larsson H, Lundholm
C, Magnusson PKE, Landén M. The risk of switch to mania
in patients with bipolar disorder during treatment with an
antidepressant alone and in combination with a mood stabilizer.
Focus (Am Psychiatr Publ) 2015; 13:68-74. [CrossRef]
- Montgomery SA. SAT-7-5 Safety of mirtazapine: a review. Eur
Neuropsychopharmacol 1995; 5:263-264. [CrossRef]
- Gao K, Kemp DE, Ganocy SJ, Muzina DJ, Xia G, Findling RL,
Calabrese JR. Treatment-emergent mania/hypomania during
antidepressant monotherapy in patients with rapid cycling
bipolar disorder. Bipolar Disord 2008; 10:907-915. [CrossRef]