H. Gürsoy PALA, Berrin ACAR, Sabahattin ALTUNYURT, Hale ARIK

Postmenopozal sağlıklı kadınlarda kemik mineral yoğunluğu – tiroid stimülan hormon ilişkisi

Amaç: Postmenopozal sağlıklı kadınlarda femoral ve lomber kemik mineral yoğunluğunun tiroid stimülan hormon düzeyi ile ilişkisini araştırmak. Gereç ve yöntem: Çalışmaya 152 postmenopozal sağlıklı kadın dahil edilmiştir. Kemik mineral yoğunluğu, DEXA ile anterior-posterior lomber (L1-L4) spine’ler ve femur üzerinden yapıldı ve TSH düzeyi kemilüminesans yöntemi kullanılarak ölçüldü. İstatistiksel analizde Pearson korelasyonu, t – testi, tek yönlü varyans analizi (ANOVA), multiple regresyon analizi kullanıldı p < 0,05 anlamlı kabul edildi. Bulgular: Tiroid stimülan hormon düzeyi ile kemik mineral yoğunluğu arasında anlamlı bir ilişki saptanmadı (toplam lomber spinal (L1-4) T skoru için p = 0,11 ve toplam femur T skoru için p = -0,03). Toplam femur T skoru ile yaş, menopoz yılı, vücut kitle indeksi arasındaki ilişki anlamlı bulundu (p

Bone mineral density and thyroid-stimulating hormone association in postmenopausal healthy women

Objective: To investigate the association between bone mineral density (BMD) and serum Thyroid-Stimulating Hormone levels in postmenopausal healthy women. Material and method: 152 postmenopausal healthy women were included in our study. We measured BMD at the lumbar spine (L1-L4) and femur using dual energy Xray absorptiometry and serum TSH concentration using chemiluminisence. Pearson's Correlation, t-test, analysis of variance (ANOVA), multiple regression analysis were used in statistical analysis and p<0.05 was considered statistically significant. Results: There was no significant relation between TSH levels and BMD scores (for lumbar spine p = 0,11 and femur p = -0,03). A significant relation was determined between the total femur T score and age, years since menopause, body mass index (VKI) (p<0.05 ). Also there was a significant relation between total lumbar spine T score and VKI, years since menopause, duration for hormone replacement therapy (p<0.05). Total femur T score was lower in natural menopause group than surgical menopause group (p=0.04). There was a significant correlation between VKI and both T scores (p < 0.01) (for femur r2 = 0.15, for lumber spine r2 =0.12) Conclusion: We did not determine a significant relation between BMD and TSH. TSH value seems not a good predictive marker for detecting bone mineral density. There was a close relation between VKI and BMD, so we conclude that VKI is a useful indicator for detecting BMD. Similar studies can be performed in premenopausal and menopausal women to show the association between TSH, VKI and BMD.

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