Talat TAVLI, Alaettin AVŞAR, Ömer KOZAN, Abdullah DOĞAN, Hasan KÖK

Koroner arter hastalığında damar tutulumunun apolipoproteinlerle ilişkisi

ISSN: 1300-6622
Yayın Aralığı: 3
Başlangıç: 2015
Yayıncı: -

Bu çalışmada, anjiokardiyografi ile koroner arter hastalığı tanısı konmuş 121 hastanın Apolipoprotein A-l, apolipoprolein B ve lipid düzeyleri, 47 olgudan oluşan kontrol grubu ile karşılaştırılarak, önceden hastalığı belirleme ve damar tutulumu açısından önemi araştırılmıştır. Apolipoprotein A-l, kontrol olguları ile karşılaştırıldığında koroner arter hastalığı grubunda (95±53 mgldl) anlamlı bir değişiklik saptanamazken (p>0.05), Apolipoprotein B düzeyi kontrol grubunda 87+44 mgldl), bir damar hastalarında (111±51 mgldl, p

The predictive value of apolipoprotein A-l, apolipoprotein B and serum lipid levels were assessed in 121 patients with angiocardiographic evidence of coronary artery disease compared to 47 normal, control subjects. There was no significant difference in apolipoprotein A-l levels of patients (95+53 mgldl) compared to the control group (95+42 mgldl, p>0.05). The levels of apolipoprotein B in single vessel disease (111+51 mgldl) and two vessel disease (118+54 mgldl) were significantly elevated compared to the control group (87+44 mgldl). Apolipoprotein B levels in three vessel disease 107+51 mg+dl) were not significantly different compared to the control group (p>0.05). In conclusion, apolipoprotein B levels were concluded to be significantly elevated in left anterior descending coronary artery disease (p<0.05). The ratio of apolipoprotein B to apolipoprotein A-l was signficantly elevated (1.69±0.8)compared to the control group (1.04+O.6) im only patients with right coronary\ artery disease. The predictive value of apolipoproteins in the assessment of the extent of the disease remains inconclusive besides other conventional tests such as the measurement of lipid levels and lipoprotein electrophoresis.